Alfaprostol, Ro-229000, K-11941, Alfavet
阿法前列醇Chemical Name: [1R-[1alpha(Z),2beta(S*),3alpha,5alpha]]-7-[2-(5-Cyclohexyl-3-hydroxy-1-pentynyl)-3,5-dihydroxycyclopentyl]-5-heptenoic acid methyl ester; 7-[(1R,2S,3R,5S)-2-[5-Cyclohexyl-3(S)-hydroxy-1-pentynyl]-3,5-dihydroxycyclopentyl]-5(Z)-heptenoic acid methyl ester; 18,19,20-Trinor-17-cyclohexyl-13,14-didehydro-PGF2alpha methyl ester; 18,19,20-Trinor-17-cyclohexyl-9,11,15-trihydroxyprosta-5-en-13-inoic acid methyl ester
CAS No. 74176-31-1
项目整合开发状态: Phase II
项目研究机构: Pfizer (Originator), Roche (Originator)
合成路线:The Wittig condensation of the bicyclic lactol (I) with 4-(methoxycarbonyl)butyl triphenylphosphonium bromide (II) by means of sodium methylsulfinyl carbanide in DMSO and simultaneous dehydrobromination gives the bis(tetrahydropyranyl) derivative (III),which is finally deprotected by a treatment with oxalic acid in refluxing acetone.
📌 参考资料/链接：
参考文献标题:Omega-nor-cycloalkyl-13,14-dehydroprostaglandins
文献作者:Gandolfi,C.; Pellegata,R.; Ceserani,R.; Usardi,M.M.(Pharmacia Corp.)
参考来源:DE 2539116; FR 2285866; FR 2378757; GB 1483880; JP 51125044; JP 58135858; US 4035415; US 4361577
📄 详细内容
合成路线:The Wittig condensation of the bicyclic lactol (I) with 4-(methoxycarbonyl)butyl triphenylphosphonium bromide (II) by means of sodium methylsulfinyl carbanide in DMSO and simultaneous dehydrobromination gives the bis(tetrahydropyranyl) derivative (III),which is finally deprotected by a treatment with oxalic acid in refluxing acetone.
参考文献标题:Alfaprostol
文献作者:Castar,J.; Serradell,M.N.; de Angelis,L.
参考来源:Drugs Fut 1985,10(1),9
产品链接: CAS No. 74176-31-1››