Amiflamine, (+)-FLA-336
阿米夫胺Chemical Name: (+)-N-[4-[2(S)-Aminopropyl]-3-methylphenyl]-N,N-dimethylamine L- tartrate
CAS No. 77518-07-1 (free base)
项目整合开发状态: Biological Testing
项目研究机构:
合成路线:The interaction of N,N-dimethyl-m-toluidine (I) and phosphorous oxychloride in dimethylformamide results in the formation of 4-dimethylamino-o-tolualdehyde (II).The condensation of this aldehyde and nitroethane (A) in the presence of ammonium acetate gives the corresponding beta-nitrostyrene (III).The preparation of 4-dimethylamino-2,alpha-dimethylphenethylamine (IV) is effected by a procedure involving the reduction of the beta-nitrostyrene (III) with lithium aluminium hydride.Finally,the racemic amine (IV) is resolved into the (S)-isomer by the use of (+)-tartaric acid (V)
📌 参考资料/链接：
参考文献标题:N-Desmethyl analogues of (+)-4-dimethylamino-2,a-dimethylphenethylamine.Synthesis and configurational relationships
文献作者:Florvall,L.; Persson,M.-L.
参考来源:Acta Chem Scand 1982,B36141
📄 详细内容
合成路线:The interaction of N,N-dimethyl-m-toluidine (I) and phosphorous oxychloride in dimethylformamide results in the formation of 4-dimethylamino-o-tolualdehyde (II).The condensation of this aldehyde and nitroethane (A) in the presence of ammonium acetate gives the corresponding beta-nitrostyrene (III).The preparation of 4-dimethylamino-2,alpha-dimethylphenethylamine (IV) is effected by a procedure involving the reduction of the beta-nitrostyrene (III) with lithium aluminium hydride.Finally,the racemic amine (IV) is resolved into the (S)-isomer by the use of (+)-tartaric acid (V)
参考文献标题:Crystal structure and absolute configuration of the dihydrobromide of a selective monoamine oxidase inhibitor: (S)-(+)-4-Dimethyl-2,a-dimethylphenethylamine
文献作者:Hjert閚,I.; Werner,P.-E.; W鋑ner,A.; Florvall,L.
参考来源:Acta Pharm Suec 1983,20123
合成路线:The interaction of N,N-dimethyl-m-toluidine (I) and phosphorous oxychloride in dimethylformamide results in the formation of 4-dimethylamino-o-tolualdehyde (II).The condensation of this aldehyde and nitroethane (A) in the presence of ammonium acetate gives the corresponding beta-nitrostyrene (III).The preparation of 4-dimethylamino-2,alpha-dimethylphenethylamine (IV) is effected by a procedure involving the reduction of the beta-nitrostyrene (III) with lithium aluminium hydride.Finally,the racemic amine (IV) is resolved into the (S)-isomer by the use of (+)-tartaric acid (V)
参考文献标题:Amiflamine
文献作者:Florvall,L.; Ask,A.-L.
参考来源:Drugs Fut 1984,9(7),491
产品链接: CAS No. 77518-07-1››