项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
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项目整合精选

Fludarabine phosphate, SHT-586, NSC-312887, 2-F-ara-AMP, 2-Fluoro-ara-AMP, Beneflur, Fludara

磷酸氟达拉滨Chemical Name: 2-Fluoro-9-(5-O-phosphono-beta-D-arabinofuranosyl)-9H-purin-6-amine; 9-(beta-D-Arabinofuranosyl)-2-fluoroadenine 5'-(dihydrogen phosphate)
CAS No. 75607-67-9
项目整合开发状态: Launc...
参考文献标题:Prodrug derivatives of 9-beta-D-arabinofuranosyl-2-fluoroadenine
文献作者:Montgomery,J.A.; Shortnacy,A.T.(US Department of Health & Human Services)
参考来源:US 4357324

Clofilium phosphate, LY-150378

磷酸氯非铵Chemical Name: [4-(p-Chlorophenyl)butyl]diethylheptylammonium phosphate (1:1); N,N-Diethyl-N-heptyl-4-(p-chlorophenyl)butylammonium phosphate (1:1); 4-Chloro-N,N-diethyl-N-heptylbenzenebutanamini...
参考文献标题:Clofilium Phosphate
文献作者:Hillier,K.; Castar,J.
参考来源:Drugs Fut 1981,6(12),764

Fosfomycin tromethamine, Fosfomycin trometamol, Z-1282, Monurol, Monuril

磷霉素氨丁三醇Chemical Name: Fosfomycin (1:1) salt with 2-ammonium-2-hydroxymethyl-1,3-propanediol; (2R,3S)-3-Methyloxirane-1-phosphonic acid mono(2-ammonium-2-hydroxymethyl-1,3-propanediol) salt
CAS No. ...
参考文献标题:Mono(2-ammonium-2-hydroxymethyl-1,3-propanediol-(2R-cis)-3-methyloxiranyl)phosphonate,its preparation and pharmaceutical compositions containing it
文献作者:Chiarino,D.; Della Bella,D.; Ferrari,V.(Zambon Group SpA)
参考来源:BE 885756; DE 3061359; EP 0027597; FR 2467856; JP 8177290; US 4863908

Glutaurine, Litoralon

磺乙谷酰胺Chemical Name: gamma-L-Glutamyl-taurine; N-(2-Sulfoethyl)-L-glutamine
CAS No. 56488-60-9
项目整合开发状态: Phase III
项目研究机构: Chinoin (Originator)
合成路线:N-carbobenzyloxy-L-glutamic acid (I) is ...
参考文献标题:Method of preparing gamma-L-glutamyl taurine
文献作者:Feuer,L.; et al.(Chinoin Pharmaceutical and Chemical Works Co.,Ltd.)
参考来源:US 4110441

Methylprednisolone suleptanate, U-67590A, Medrosol, Promedrol

磺庚甲泼尼龙Chemical Name: 8-Oxo-8-[N-(2-sulfoethyl)-N-methylamino]octanocic acid C-21 ester with 11beta,17,21-trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione,monosodium salt; 11beta,17-Dihydroxy-6alpha...
参考文献标题:Sulfonate containing ester prodrugs of corticosteroids
文献作者:Anderson,B.D.; Conradi,R.A.(Pharmacia Corp.)
参考来源:JP 1984137500; US 4472392

Sulotroban, SK&F-95587, BM-13177

磺曲苯Chemical Name: [4-[2-[(Phenylsulfonyl)amino]ethyl]phenoxy]acetic acid
CAS No. 72131-33-0
项目整合开发状态: Phase III
项目研究机构: Roche (Originator)
合成路线:The reaction of 4-[2-(acetylamino)ethyl]phen...
参考文献标题:Process for the preparation of 1,4-dihydropyridines and cpds.used in this process
文献作者:Karup,G.L.; Preikschat,H.F.(GEA A/S Farmaceutisk Fabrik)
参考来源:WO 9925688

Sulofenur, LY-186641

磺氯苯脲Chemical Name: N-(4-Chlorophenylaminocarbonyl)indane-5-sulfonamide; N-(5-Indansulsulfonyl)-N'-(4-chlorophenyl)urea
CAS No. 110311-27-8
项目整合开发状态: Phase II
项目研究机构: Lilly (Originator)
合成路...
参考文献标题:Novel agents effective against solid tumors: The diarylsulfonylureas.Synthesis,activities and analysis of quantitative structure-activity relationships
文献作者:Grossman,C.S.; Kramer,K.E.; Crowell,T.A.; Grindey,G.B.; Rieder,B.J.; Rinzel,S.M.; Harper,R.W.; Howbert,J.J.; Tao,E.V.; Aikins,J.; Shaw,W.N.; Poore,G.A.; Todd,G.C.
参考来源:J Med Chem 1990,33(9),2393-407

Fondaparinux sodium, Fondaparin sodium, SR-90107, Org-31540, SR-90107A, Quixidar, Arixtra

磺达肝癸钠磺达肝癸钠 Chemical Name: O-[2-Deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranosyl]-(1--4)-O-(beta-D-glucopyranurosonyl)-(1--4)-O-[2-deoxy-3,6-di-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranosyl]-(1--...
参考文献标题:Synthesis of heparin fragments: A methyl alpha-pentaoside with high affinity for antithrombin III
文献作者:Petitou,M.; Duchaussoy,P.; Lederman,I.; Choay,J.; Jacquinet,J.C.; Sinay,P.; Torri,G.
参考来源:Carbohydr Res 1987,16767

Fostriecin sodium, PD-110161, NSC-339638, CL-1565A, CI-920

福司曲星福司曲星 Chemical Name: 5,6-Dihydro-6(R)-[3(R),6(R),13-trihydroxy-3-methyl-4(R)-(phosphonooxy)-1(E),7(Z),9(Z),11(E)-tridecatetraenyl]-2H-pyran-2-one monosodium salt; (2Z,5R,6E,8R,9R,11R,12Z,14Z,16E)-...
参考文献标题:Total synthesis of fostriecin (CI-920)
文献作者:Boger,D.L.; Ichikawa,S.; Zhong,W.
参考来源:J Am Chem Soc 2001,123(18),4161

Fudosteine, SS-320A, SS-320, Spelear, Cleanal

福多司坦Chemical Name: S-(3-Hydroxypropyl)-L-cysteine; 2(R)-Amino-3-(3-hydroxypropylsulfanyl)propionic acid
CAS No. 13189-98-5
项目整合开发状态: Launched-2001
项目研究机构: SSP (Originator), Mitsubishi Pharma ...
参考文献标题:Expectorant comprising hydroxy-alkylcysteine deriv
文献作者:Itoh,Y.; Mizuno,H.; Kiyohara,C.; Sato,S.; Katori,T.(SSP Co.,Ltd.)
参考来源:EP 0346882; EP 0346883; JP 1990003674; US 4906665