Fosfomycin tromethamine, Fosfomycin trometamol, Z-1282, Monurol, Monuril
磷霉素氨丁三醇Chemical Name: Fosfomycin (1:1) salt with 2-ammonium-2-hydroxymethyl-1,3-propanediol; (2R,3S)-3-Methyloxirane-1-phosphonic acid mono(2-ammonium-2-hydroxymethyl-1,3-propanediol) salt
CAS No. 78964-85-9
项目整合开发状态: Launched-1988
项目研究机构: Zambon (Originator), Madaus (Not Determined), Purdue Pharma (Not Determined), Forest (Licensee), Pharmax (Licensee)
合成路线:By treatment of bis(2-ammonium-2-hydroxymethyl-1,3-propanediol) (2R-cis)(3-methyl-2-oxyranyl)phosphonate (I) with p-toluenesulfonic acid in hot ethanol.
📌 参考资料/链接：
参考文献标题:Mono(2-ammonium-2-hydroxymethyl-1,3-propanediol-(2R-cis)-3-methyloxiranyl)phosphonate,its preparation and pharmaceutical compositions containing it
文献作者:Chiarino,D.; Della Bella,D.; Ferrari,V.(Zambon Group SpA)
参考来源:BE 885756; DE 3061359; EP 0027597; FR 2467856; JP 8177290; US 4863908
📄 详细内容
合成路线:By treatment of bis(2-ammonium-2-hydroxymethyl-1,3-propanediol) (2R-cis)(3-methyl-2-oxyranyl)phosphonate (I) with p-toluenesulfonic acid in hot ethanol.
参考文献标题:Fosfomycin Trometamol
文献作者:Serradell,M.N.; Castar,J.
参考来源:Drugs Fut 1986,11(1),16
产品链接: CAS No. 78964-85-9››