Fudosteine, SS-320A, SS-320, Spelear, Cleanal
福多司坦Chemical Name: S-(3-Hydroxypropyl)-L-cysteine; 2(R)-Amino-3-(3-hydroxypropylsulfanyl)propionic acid
CAS No. 13189-98-5
项目整合开发状态: Launched-2001
项目研究机构: SSP (Originator), Mitsubishi Pharma (Licensee)
合成路线:Fudosteine has been obtained by two similar ways:1) By condensation of L-cysteine (I) with 3-bromopropyl alcohol (II) by means of NaOH in water at room temperature.2) By condensation of L-cysteine (I) with allyl alcohol (III) by means of potassium persulfate in water.
📌 参考资料/链接：
参考文献标题:Expectorant comprising hydroxy-alkylcysteine deriv
文献作者:Itoh,Y.; Mizuno,H.; Kiyohara,C.; Sato,S.; Katori,T.(SSP Co.,Ltd.)
参考来源:EP 0346882; EP 0346883; JP 1990003674; US 4906665
📄 详细内容
合成路线:Fudosteine has been obtained by two similar ways:1) By condensation of L-cysteine (I) with 3-bromopropyl alcohol (II) by means of NaOH in water at room temperature.2) By condensation of L-cysteine (I) with allyl alcohol (III) by means of potassium persulfate in water.
参考文献标题:Preparation method of S-hydroxypropyl-L-cysteine
文献作者:Ito,Y.; Kuriyama,T.; Ogawa,M.; Sato,S.; Kuraishi,T.(SSP Co.,Ltd.)
参考来源:JP 1996119932
合成路线:Fudosteine has been obtained by two similar ways:1) By condensation of L-cysteine (I) with 3-bromopropyl alcohol (II) by means of NaOH in water at room temperature.2) By condensation of L-cysteine (I) with allyl alcohol (III) by means of potassium persulfate in water.
参考文献标题:Fudosteine
文献作者:Castar,J.; Leeson,P.; Wroblewski,T.
参考来源:Drugs Fut 1998,23(4),374
合成路线:Fudosteine has been obtained by two similar ways:1) By condensation of L-cysteine (I) with 3-bromopropyl alcohol (II) by means of NaOH in water at room temperature.2) By condensation of L-cysteine (I) with allyl alcohol (III) by means of potassium persulfate in water.
参考文献标题:The formation of 2-hydroxypropylmercapturic acid from 1-halogenopropanes in the rat
文献作者:Barnsley,E.A.
参考来源:Biochem J 1996,100362-72
产品链接: CAS No. 13189-98-5››