项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
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项目整合精选

Ioflupane (123I), [123I]FP-CIT, [123I]beta-CIT-FP, DatScan

碘氟潘Chemical Name: (1R,2S,3S,5S)-8-(3-Fluoropropyl)-3-(4-[123I]iodophenyl)-8-azabicyclo[3.2.1]octane-2-carboxylic acid methyl ester
CAS No. 155798-07-5
项目整合开发状态: Launched-2000
项目研究机构: Amersham...
参考文献标题:N-omega-Fluoroalkyl analogs of (1R)-2beta-carbomethoxy-3beta-(4-iodophenyl)-tropane (beta-CIT): Radiotracers for positron emission tomography and single photon emission computed tomography imaging of dopamine transporters
文献作者:Neumeyer,J.L.; Wang,S.; Gao,Y.; Milius,R.A.; Kula,N.S.; Campbell,A.; Baldessarini,R.J.; Zea-Ponce,Y.; Baldwin,R.M.; Innis,R.B.
参考来源:J Med Chem 1994,37(11),1558

Ioversol, MU-328(as syringe), MP-328, Optiject, Optiray

碘氟醇Chemical Name: N,N'-Bis(2,3-dihydroxypropyl)-5-[N-(2-hydroxyethyl)glycolamido]-2,4,6-triiodoisophthalamide; N,N'-Bis(2,3-dihydroxypropyl)-5-[(hydroxyacetyl)(2-hydroxyethyl)amino]-2,4,6-triiodo-1,3-...
参考文献标题:Cpds.suitable for X-ray visualisation methods
文献作者:Lin,Y.(Mallinckrodt Medical Inc.)
参考来源:EP 0083964; US 4396598

Iomeprol, E-7337, B-16880, Imeron, Iomeron

碘美普尔Chemical Name: N,N'-Bis(2,3-dihydroxypropyl)-2,4,6-triiodo-5-(N-methylglycolamido)isophthalamide; N,N'-Bis(2,3-dihydroxypropyl)-5-[(hydroxyacetyl)methylamino]-2,4,6-triiodo-1,3-benzenedicarboxamid...
参考文献标题:Derivs.of 2,4,6-triiodo-isophthalic acid,processes for their synthesis and x-ray contrasting materials containing these
文献作者:Felder,E.; Pitre,D.(Bracco SpA)
参考来源:EP 0026281; US 4352788

Idoxuridine, NSC-39661, IdUrd, IDUR, IDU, IUDR, Herpid

碘苷Chemical Name: 2'-Deoxy-5-iodouridine
CAS No. 54-42-2
项目整合开发状态: Launched
项目研究机构: National Cancer Institute (Originator), Yamanouchi (Not Determined), NeoPharm (Codevelopment)
合成路线:Idoxur...
参考文献标题:New method for the preparation of a uridine deriv.and products used in this method
文献作者:Amiard,G.; Torelli,V.(Aventis Pharma SA)
参考来源:FR 1336866; GB 1024156

Iosimide, Univist

碘西胺Chemical Name: 2,4,6-Triiodobenzene-1,3,5-tricarboxylic acid tris[bis(2-hydroxyethyl)]triamide
CAS No. 79211-10-2
项目整合开发状态: Pre-Registered
项目研究机构: Schering AG (Originator)
合成路线:The amin...
参考文献标题:Non-ionic 5-C substd.2,4,6-triiodo-isophthalic ac
文献作者:Gries,H.; Pfeiffer,H.; Speck,U.; Mzel,W.(Schering AG)
参考来源:DE 3001292; EP 0032387; US 5047228

Carboprostacyclin, Carbacyclin, U-55185

碳环素(碳环PGI 2)Chemical Name: [3aS-[2E,3aalpha,4alpha(1E,3R*),5beta,6aalpha]]-5-[Hexahydro-5-hydroxy-4-(3-hydroxy-1-octenyl)-2(1H)-pentalenylidene]pentanoic acid; dl-9a-Deoxy-9a-methylene-PGI2
CAS No....
参考文献标题:Carbacyclin
文献作者:Castar,J.; Hillier,K.
参考来源:Drugs Fut 1981,6(12),753

Fosquidone, GR-63178X, GR-63178A, NSC-D-611615, GR-63178G(sodium salt)

磷喹酮磷喹酮 Chemical Name: (R,S)-9-[Benzyloxy(hydroxy)phosphoryloxy]-14-methyl-5,14-dihydrobenz[5,6]isoindolo[2,1-b]isoquinoline-8,13-dione; Benzyl (?-5,8,13,14-tetrahydro-14-methyl-8,13-dioxobenz[5,6]iso...
参考文献标题:Dioxobenz[5,6]isoindolo[2,1-b]isoquinoline derivs
文献作者:Phillips,G.H.; Jones,P.S.; Cooper,M.E.(Glaxo Wellcome plc)
参考来源:AU 8776203; BE 1002110; CH 672489; DE 3725185; FR 2602233; JP 1988093783; JP 1990000187; US 4851399

Phosphenytoin sodium, Fosphenytoin sodium, ACC-9653-010, CI-982, ACC-9653, Pro-Epanutin, Cerebyx

磷苯妥英钠磷苯妥英 Chemical Name: 3-(Hydroxymethyl)-5,5-diphenylhydantoin phosphate ester disodium salt; 5,5-Diphenyl-3-[(phosphonooxy)methyl]-2,4-imidazolidinedione disodium salt; Disodium 5,5-diphenylhydant...
参考文献标题:ACC-9653
文献作者:Prous,J.; Castar,J.
参考来源:Drugs Fut 1989,14(7),611

CI-201678(HCl), Cpd-201678, 201678

磷酸二氢(3β,5β,14xi,22R)-3,14,25-三羟基-6-羰基胆甾-7-烯-22-酯Chemical Name: (-)-(4S,5aR)-5-Ethyl-9,10-dihydroxy-4-propyl-4,5,5a,6-tetrahydrodibenz[cd,f]indole
CAS No. 82166-77-6, 82188-32-7 ((4S)-trans-isomer, ...
参考文献标题:Nouveaux d閞iv閟 du dibenz[cd,f]indole,leur pr閜aration et leur application comme m閐icaments
文献作者:Giger,R.K.A.(Novartis AG)
参考来源:DE 3124086; FR 2485530; FR 2510996; WO 8200143

Oseltamivir phosphate, Ro-64-0796/002, GS-4104/002, Ro-64-0796(free base), GS-4104(free base), Tamiflu

磷酸奥司他韦奥司他韦Chemical Name: (3R,4R,5S)-4-Acetamido-5-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylic acid ethyl ester phosphate (1:1)
CAS No. 204255-11-8, 209965-30-0 (citrate (1:1)), 196618-13-0 ...
参考文献标题:Novel selective inhibitors of viral or bacterial neuraminidases
文献作者:Bischofberger,N.W.; Kim,C.U.; Lew,W.; Liu,H.; Williams,M.A.(Gilead Sciences Inc.)
参考来源:EP 0759917; EP 0976734; JP 1999501908; WO 9626933