Iosimide, Univist
碘西胺Chemical Name: 2,4,6-Triiodobenzene-1,3,5-tricarboxylic acid tris[bis(2-hydroxyethyl)]triamide
CAS No. 79211-10-2
项目整合开发状态: Pre-Registered
项目研究机构: Schering AG (Originator)
合成路线:The amino group of iodamic acid (I) is converted to the nitrile (II) via diazotization and a Sandmeyer reaction.Subsequent hydrolysis via the amide (III) yields triiodotrimesic acid (IV).The trichloride of this acid (V) is converted to iosimide by reaction with diethanolamine.
📌 参考资料/链接：
参考文献标题:Non-ionic 5-C substd.2,4,6-triiodo-isophthalic ac
文献作者:Gries,H.; Pfeiffer,H.; Speck,U.; Mzel,W.(Schering AG)
参考来源:DE 3001292; EP 0032387; US 5047228
📄 详细内容
合成路线:The amino group of iodamic acid (I) is converted to the nitrile (II) via diazotization and a Sandmeyer reaction.Subsequent hydrolysis via the amide (III) yields triiodotrimesic acid (IV).The trichloride of this acid (V) is converted to iosimide by reaction with diethanolamine.
参考文献标题:Iosimide
文献作者:Gries,H.
参考来源:Drugs Fut 1988,13(3),228
产品链接: CAS No. 79211-10-2››