项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
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项目整合精选

Sertaconazole nitrate, FI-7045(free base), Ertaczo, Ginedermofix, Zalain, Dermoseptic, Extens, Dermofix, Fisderm

硝酸舍他康唑舍他康唑 Chemical Name: (R,S)-(?-1-[2-(7-Chlorobenzo[b]thien-3-ylmethoxy)-2-(2,4-dichlorophenyl)ethyl]imidazole nitrate
CAS No. 99592-39-9, 99592-32-2 (free base)
项目整合开发状态: Launched-1992
...
参考文献标题:Synthesis and antimycotic activity of (benzo[b]thienyl)methyl ethers of 1 -(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethanol and of (Z)-1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethanone oxime
文献作者:Moreno-Ma馻s,M.; Raga,M.M.; Palac韓,C.; Ortiz,J.A.; Cuberes,M.R.; Castell? J.M.
参考来源:Arzneim-Forsch Drug Res 1992,42(5a),691

Fenticonazole nitrate, Rec-151476B free base, Rec-151476, Lomexin

硝酸芬替康唑芬替康唑 Chemical Name: (?-1-[2-(2,4-Dichlorophenyl)-2-[[4-(phenylthio)phenyl]methoxy]ethyl]-1H-imidazole mononitrate
CAS No. 73151-29-8, 72479-26-6 (free base)
项目整合开发状态: Launched-1986
项目研...
参考文献标题:Substituted dibenzyl ethers and parmaceutical compositions containing said ethers for the treatment of infections
文献作者:Nardi,D.; Massarani,E.; Tajana,A.; Veronese,M.(Recordati Industria Chimica e Farmaceutica SpA)
参考来源:DE 2917244; FR 2426047; GB 2025395; US 4221803

Gallium nitrate, NSC-15200, Ganite

硝酸镓Chemical Name: Gallium (III) nitrate
CAS No. 13494-90-1, 135886-70-3 (nonahydrate)
项目整合开发状态: Launched-1991
项目研究机构: Genta (Orphan Drug), Lyphomed (Orphan Drug), Fujisawa (Originator), Lypho...
参考文献标题:Gallium nitrate
文献作者:Castar,J.; Serradell,M.N.; Hopkins,S.J.; Blancafort,P.
参考来源:Drugs Fut 1981,6(4),228

Tiacrilast, Ro-22-3747/007(Na salt), Ro-22-3747/000, Ro-22-3747

硫克司特Chemical Name: (E)-3-[(6-Methylthio)-4-oxo-3(4H)-quinazolinyl]-2-propenoic acid; (E)-6-(Methylthio)-4-oxo-3(4H)-uinazolineacrylic acid
CAS No. 78299-53-3, 111868-63-4 (Na salt, monohydrate)
...
参考文献标题:Trans-3-(4-oxo-4H-quinazolin-3-yl)-2-propenoic acid derivatives
文献作者:Lemahieu,R.A.; Nason,W.C.(Hoffmann-La Roche,Inc.)
参考来源:EP 0023594; JP 8125167; US 4281127

Sulprostone, ZK-57671, SH-B-286, CP-34089, Nalador

硫前列酮Chemical Name: 16-Phenoxy-omega-17,18,19,20-tetranor-PGE2 methylsulfonamide
CAS No. 60325-46-4
项目整合开发状态: Launched-1981
项目研究机构: Schering AG (Originator)
合成路线:The condensation of methyl ...
参考文献标题:Sulprostone
文献作者:Castar,J.; Wescott,A.L.
参考来源:Drugs Fut 1978,3(1),59

Sulopenem, CP-65207-S, CP-70429

硫培南Chemical Name: (5R,6S)-6-[1(R)-Hydroxyethyl]-2-[(1R)-1-oxotetrahydrothiophen-3(S)-ylthio]-2-penem-3-carboxylic acid
CAS No. 120788-07-0
项目整合开发状态: Phase III
项目研究机构: Pfizer (Originator)
合...
参考文献标题:Diastereomeric 5R,6S-6-(1R-hydroxyethyl)-2-(cis-1-oxo-3-thiolanylthio)-2-penem-3-carboxylic acids
文献作者:Volkmann,R.A.(Pfizer Inc.)
参考来源:JP 1995278137; US 5013729; WO 8808845

Tioxaprofen, EMD-26644

硫恶洛芬Chemical Name: 2-[4,5-Bis(4-chlorophenyl)oxazol-2-ylsulfanyl]propionic acid
CAS No. 40198-53-6
项目整合开发状态: Not Determined
项目研究机构:
合成路线:The reaction of 4,5-bis(p-chlorophenyl)-2-oxazolon...
参考文献标题:
文献作者:Dahm,J.; et al.
参考来源:AU 323158; AU 327889; AU 327890; AU 327891; AU 327892; AU 328440; FR 2140632; GB 1331408; US 3933840; ZA 7203502

Clopidogrel bisulfate, Clopidogrel hydrogensulfate, DV-7314, SR-25990C, Iscover, Plavix

硫酸氯吡格雷氯吡格雷 Chemical Name: (+)-(S)-2-(2-Chlorophenyl)-2-(4,5,6,7-tetrahydrothieno[3,2-c]pyridin-5-yl)acetic acid methyl ester hydrogensulfate
CAS No. 120202-66-6, 113665-84-2 (free base), 94188-84-...
参考文献标题:Novel thieno(3,2-c)pyridine derivs.,process for their preparation and their application in therapy
文献作者:Aubert,D.; Ferrand,C.; Maffrand,J.-P.(Sanofi-Synthabo )
参考来源:EP 0099802; US 4529596

Salbutamol sulfate, Albuterol sulfate, AH-3365, Pediavent, Ventoline, Ventolin, Proventil-HFA, Proventil, Volmax, Ventolin easy-breathe, Salbutamol Diskus, Proventil Repetabs, Ventolin Nebules, Buventol Easyhaler, Accuvent, Pulvinal salbutamol, Sultanol,

硫酸沙丁胺醇沙丁胺醇 Chemical Name: alpha1-[(tert-Butylamino)methyl]-4-hydroxy-m-xylene-alpha,alpha'-diol sulfate (2:1); alpha1-(1,1-Dimethylethylaminomethyl)-4-hydroxy-1,3-benzenedimethanol sulfate (2:1)
C...
参考文献标题:Saligenin analogs of sympathomimetic catecholamines
文献作者:Collin,D.T.; Hartley,D.; Jack,D.; Lunts,L.H.; Press,J.C.; Ritchie,A.C.; Toon,P.
参考来源:J Med Chem 1970,13(4),674-680

Guanadrel sulfate, U-28288D, CL-1388R, Hylorel

硫酸胍那决尔胍那决尔 Chemical Name: (1,4-Dioxaspiro[4.5]dec-2-yl)guanidine sulfate
CAS No. 22195-34-2, 40580-59-4 (free base)
项目整合开发状态: Launched-1983
项目研究机构: Pfizer (Originator), Celltech (Not Determi...
参考文献标题:Process for the preparation of 1,3-dioxolan-4-yl-alcoyl-guanidines and its intermediates
文献作者:Aaron,J.E.Jr.; Hardie,W.R.
参考来源:FR 1522153