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  • 项目整合精选
    • 聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
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    项目整合精选

  • Dapiprazole hydrochloride, AF-2139, Remydrial, Rev-Eyes, Reversil, Glamidolo

    盐酸达哌唑 达哌唑 Chemical Name: 5,6,7,8-Tetrahydro-3-[2-(4-o-tolyl-1-piperazinyl)-ethyl]-s-triazolo[4,3-a]pyridine monohydrochloride
    CAS No. 72822-13-0, 72822-12-9 (free base)
    项目整合开发状态: Launched-1986 参考文献标题:Cycloalkyltriazoles and process for obtaining same
    文献作者:Silvestrini,B.; Baiocchi,L.(ACRAF SpA)
    参考来源:FR 2423221; GB 2020269; JP 54157576; NL 7902489; US 4252721

  • Rimantadine hydrochloride, EXP-126, Oclovir, Flumadine, Roflual

    盐酸金刚乙胺 1-金刚烷乙胺 Chemical Name: alpha-Methyl-1-adamantanemethylamine hydrochloride; alpha-Methyltricyclo[3.3.1.1(3,7)]decane-1-methanamine hydrochloride
    CAS No. 1501-84-4, 13392-28-4 (free base)
    项...
    参考文献标题:Verfahren zur Herstellung von alpha-Methyl-polycyclomethylaminen
    文献作者:Brake,L.D.(DuPont Pharmaceuticals Co.)
    参考来源:CH 495944; DE 1668571; FR 1568056; US 3489802

  • Nazasetron hydrochloride, Azasetron hydrochloride, Y-25130, Serotone

    盐酸阿扎司琼 2H-1,4-苯甲氧嗪-8-羧酰胺,N-1-氮双环[2.2.2]辛-3-酰基-6-氯-3,4-二氢-4-甲基-3-氧-,一盐酸盐,(-)-(9CI) Chemical Name: (?-N-(1-Azabicyclo[2.2.2]oct-3-yl)-6-chloro-4-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-8-carboxamide...
    参考文献标题:Benzoxazine cpds.and pharmaceutical use thereof
    文献作者:Tahara,T.; Kawakita,T.; Yasumoto,M.; Fukuda,T.(Welfide Corporation)
    参考来源:EP 0313393; JP 1989207290; JP 1990005415; US 4892872

  • Arbidol, Arbidol

    盐酸阿比朵尔Chemical Name: 6-Bromo-4-(dimethylaminomethyl)-5-hydroxy-1-methyl-2-(phenylthiomethyl)-1H-indole-3-carboxylic acid ethyl ester hydrochloride monohydrate
    CAS No. 131707-23-8
    项目整合开发状态: Launc...
    参考文献标题:Ethyl ester 6-bromine-5-hydroxy-4-dimethyl-aminomethyl-1-methyl-2-phenylthiomethyl indole-3-carboxylic acid HCl H20,method of obtaining it and a pharmaceutical preparation of antiviral,interferon-inducing and immunomodulating action based on it
    文献作者:Grinev,A.N.; Pershin,G.N.(All-Russian Chemical-Pharmaceutical Research Institute; Nauchno-Issledovatelsky Institut)
    参考来源:US 5198552; WO 9008135

  • Acotiamide hydrochloride hydrate, YM-443, Z-338

    盐酸阿考替胺 阿考替胺 Chemical Name: N-[4-[N-[2-(Diisopropylamino)ethyl]carbamoyl]thiazol-2-yl]-2-hydroxy-4,5-dimethoxybenzamide hydrochloride trihydrate; N-[2-(Diisopropylamino)ethyl]-2-(2-hydroxy-4,5-dimethox...
    参考文献标题:Aminothiazole derivs.,drug containing the same and intermediate in the production of the cpds.
    文献作者:Nagasawa,M.; Murata,M.; Nishioka,H.; Kurimoto,T.; Ueki,S.; Kitagawa,O.(Zeria Pharmaceutical Co.,Ltd.)
    参考来源:EP 0870765; US 5981557; WO 9636619

  • Anagrelide hydrochloride, BMY-26538-01, BL-4162A, Thromboreductin, Xagrid, Agrylin, Agrelin

    盐酸阿那格雷 阿那格雷 Chemical Name: 6,7-Dichloro-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-2-one hydrochloride; 6,7-Dichloro-3,5-dihydroimidazo[2,1-b]quinazolin-2(1H)-one hydrochloride; 6,7-Dichloro-1,5-dihyd...
    参考文献标题:Preparation of 6,7-dichloro-1,5-dihydroimidazo[2,1-b]quinazolin-2(3H)-one
    文献作者:Jenks,T.A.; Beverung,W.N.Jr.; Partyka,R.A.(Bristol-Myers Squibb Co.)
    参考来源:CA 1137474

  • Azimilide hydrochloride, NE-10064, Stedicor

    盐酸阿齐利特 阿齐利特 Chemical Name: (E)-1-[5-(4-Chlorophenyl)furan-2-ylmethyleneamino]-3-[4-(4-methylpiperazin-1-yl)butyl]imidazolidine-2,4-dione dihydrochloride
    CAS No. 149888-94-8, 149908-53-2 (free base)...
    参考文献标题:Novel 4-oxocyclic ureas useful as antiarrhythmic and antifibrillatory agents
    文献作者:Pelosi,S.S.Jr.; Yu,C.-NN.; Calcagno,M.A.(The Procter & Gamble Co.)
    参考来源:EP 0598061; JP 1994509804; US 5462940; WO 9304061

  • Ranitidine hydrochloride, AH-19065, Quantor, Toriol, Tanidina, Azantac, Zantic, Zantac

    盐酸雷尼替丁Chemical Name: N-[2-[5-(Dimethylaminomethyl)furan-2-ylmethylsulfanyl]ethyl]-N'-methyl-2-nitrovinylene-1,1-diamine hydrochloride
    CAS No. 66357-59-3
    项目整合开发状态: Launched-1981
    项目研究机构: GlaxoS...
    参考文献标题:Ranitidine
    文献作者:Serradell,M.N.; Blancafort,P.; Castar,J.; Hillier,K.
    参考来源:Drugs Fut 1979,4(9),663

  • Keoxifene hydrochloride, Raloxifene hydrochloride, LY-139481(free base), LY-156758, Optruma, Loxifen, Evista

    盐酸雷洛昔芬 雷洛昔芬 Chemical Name: 1-[6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl]-1-[4-[2-(1-piperidinyl)ethoxy]phenyl]methanone hydrochloride; 6-Hydroxy-2-(4-hydroxyphenyl)-3-[4-[2-(1-piperidinyl)ethox...
    参考文献标题:Keoxifene
    文献作者:Pento,J.T.
    参考来源:Drugs Fut 1984,9(7),516

  • Ramosetron hydrochloride, YM-060, Nasea OD, Nasea

    盐酸雷莫司琼 拉莫司琼 Chemical Name: (-)-5(R)-[(1-Methylindol-3-yl)carbonyl]-4,5,6,7-tetrahydrobenzimidazole hydrochloride
    CAS No. 132907-72-3, 132036-88-5 (free base)
    项目整合开发状态: Launched-1996
    项目研究机构: ...
    参考文献标题:Tetrahydrobenzimidazole derivs
    文献作者:Ohta,M.; Koide,T.; Suzuki,T.; Matsuhisa,A.; Miyata,K.; Ohmori,J.-Y.; Yanagisawa,I.(Yamanouchi Pharmaceutical Co.,Ltd.)
    参考来源:AU 9048890; EP 0381422; JP 1991223278; US 5344927

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