Rimantadine hydrochloride, EXP-126, Oclovir, Flumadine, Roflual
盐酸金刚乙胺 1-金刚烷乙胺 Chemical Name: alpha-Methyl-1-adamantanemethylamine hydrochloride; alpha-Methyltricyclo[3.3.1.1(3,7)]decane-1-methanamine hydrochloride
CAS No. 1501-84-4, 13392-28-4 (free base)
项目整合开发状态: Launched-1987
项目研究机构: Bristol-Myers Squibb (Originator), Roche (Originator), Forest (Licensee)
合成路线:The compound can be obtained by two different ways:1) The reaction of 1-acetyladamantane (I) with hydroxylamine gives the corresponding oxime (II),which is then reduced with LiAlH4 in THF.2) By reaction of (I) with ammonia and H2 with a catalyst of Co on diatomite.
📌 参考资料/链接：
参考文献标题:Verfahren zur Herstellung von alpha-Methyl-polycyclomethylaminen
文献作者:Brake,L.D.(DuPont Pharmaceuticals Co.)
参考来源:CH 495944; DE 1668571; FR 1568056; US 3489802
📄 详细内容
合成路线:The compound can be obtained by two different ways:1) The reaction of 1-acetyladamantane (I) with hydroxylamine gives the corresponding oxime (II),which is then reduced with LiAlH4 in THF.2) By reaction of (I) with ammonia and H2 with a catalyst of Co on diatomite.
参考文献标题:Adamantanes and tricyclo[4.3.1.1(3,8)]undecanes
文献作者:Prichard,W.W.(DuPont Pharmaceuticals Co.)
参考来源:FR 1572956; GB 1069563; NL 6408505; US 3352912
合成路线:The compound can be obtained by two different ways:1) The reaction of 1-acetyladamantane (I) with hydroxylamine gives the corresponding oxime (II),which is then reduced with LiAlH4 in THF.2) By reaction of (I) with ammonia and H2 with a catalyst of Co on diatomite.
参考文献标题:Rimantadine Hydrochloride
文献作者:Serradell,M.N.; Castar,J.; Robinson,C.P.
参考来源:Drugs Fut 1984,9(9),660
产品链接: CAS No. 1501-84-4›› 产品链接: CAS No.13392-28-4››