Tioxaprofen, EMD-26644
硫恶洛芬Chemical Name: 2-[4,5-Bis(4-chlorophenyl)oxazol-2-ylsulfanyl]propionic acid
CAS No. 40198-53-6
项目整合开发状态: Not Determined
项目研究机构:
合成路线:The reaction of 4,5-bis(p-chlorophenyl)-2-oxazolone (I) with P2S5 in boiling xylene gives 2-mercapto-4,5-bis(p-chlorophenyl)oxazole (II),which by reaction with ethyl 2-bromopropionate (III) by means of NaH in DMF yields ethyl 2-[4,5-bis(p-chlorophenyl)-2-oxazolylmercapto]propionate (IV).Finally this compound is hydrolyzed with K2CO3 in refluxing ethanol.Compound (II) can also be obtained by cyclization of 4,4'-dichlorobenzoin (V) with HSCN (VI).
📌 参考资料/链接：
参考文献标题:
文献作者:Dahm,J.; et al.
参考来源:AU 323158; AU 327889; AU 327890; AU 327891; AU 327892; AU 328440; FR 2140632; GB 1331408; US 3933840; ZA 7203502
📄 详细内容
合成路线:The reaction of 4,5-bis(p-chlorophenyl)-2-oxazolone (I) with P2S5 in boiling xylene gives 2-mercapto-4,5-bis(p-chlorophenyl)oxazole (II),which by reaction with ethyl 2-bromopropionate (III) by means of NaH in DMF yields ethyl 2-[4,5-bis(p-chlorophenyl)-2-oxazolylmercapto]propionate (IV).Finally this compound is hydrolyzed with K2CO3 in refluxing ethanol.Compound (II) can also be obtained by cyclization of 4,4'-dichlorobenzoin (V) with HSCN (VI).
参考文献标题:Tioxaprofen
文献作者:Castar,J.; Garc韆 Rafanell,J.
参考来源:Drugs Fut 1978,3(8),615
产品链接: CAS No. 40198-53-6››