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项目整合精选>>>Sertaconazole nitrate, FI-7045(free base), Ertaczo, Ginedermofix, Zalain, Dermoseptic, Extens, Dermofix, Fisderm
Sertaconazole nitrate, FI-7045(free base), Ertaczo, Ginedermofix, Zalain, Dermoseptic, Extens, Dermofix, Fisderm
硝酸舍他康唑 舍他康唑 Chemical Name: (R,S)-(?-1-[2-(7-Chlorobenzo[b]thien-3-ylmethoxy)-2-(2,4-dichlorophenyl)ethyl]imidazole nitrate
CAS No. 99592-39-9, 99592-32-2 (free base)
项目整合开发状态: Launched-1992
项目研究机构: Ferrer (Originator), Robert Labs. (Originator), Mylan (Licensee)
合成路线:Sertaconazole nitrate has been synthesized by condensation of 1-(2,4-dichlorophenyl)-2-(1-imidazolyl)ethanol (I) with 3-(bromomethyl)-7-chlorobenzo[b]thiophene (II) by means of NaH in HMPT,followed by salification with HNO3.
📌 参考资料/链接：
参考文献标题:Synthesis and antimycotic activity of (benzo[b]thienyl)methyl ethers of 1 -(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethanol and of (Z)-1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethanone oxime
文献作者:Moreno-Ma馻s,M.; Raga,M.M.; Palac韓,C.; Ortiz,J.A.; Cuberes,M.R.; Castell? J.M.
参考来源:Arzneim-Forsch Drug Res 1992,42(5a),691