Ioflupane (123I), [123I]FP-CIT, [123I]beta-CIT-FP, DatScan

碘氟潘Chemical Name: (1R,2S,3S,5S)-8-(3-Fluoropropyl)-3-(4-[123I]iodophenyl)-8-azabicyclo[3.2.1]octane-2-carboxylic acid methyl ester
CAS No. 155798-07-5
项目整合开发状态: Launched-2000
项目研究机构: Amersham (Originator), Nihon Medi-Physics (Codevelopment)
合成路线:3beta-(4-Iodophenyl)nortropane-2beta-carboxylic acid methyl ester (I) was alkylated with 1-bromo-3-fluoropropane (II) in triethylamine to give the N-fluoropropyl derivative (III).Stannylation of the iodophenyl ring of (III) by Pd(0)-catalyzed reaction with hexamethylditin afforded the corresponding 4-(trimethylstannyl)phenyl tropane (IV).The 123I-labeled compound was then prepared by iododestannylation of (IV) with Na[123I] in the presence of peracetic acid.