Glutaurine, Litoralon
磺乙谷酰胺Chemical Name: gamma-L-Glutamyl-taurine; N-(2-Sulfoethyl)-L-glutamine
CAS No. 56488-60-9
项目整合开发状态: Phase III
项目研究机构: Chinoin (Originator)
合成路线:N-carbobenzyloxy-L-glutamic acid (I) is converted to the anhydride (II).Reaction of (II) with benzyl alcohol gives a mixture of half esters from which the halt ester (III) is isolated as the dicyclohexylamine salt.(III) is esterified with 4-nitrophenol (IV) with the aid of dicyclohexyl carbodiimide and the product (V) is reacted with taurine (VI).Deprotection of the resulting peptide (VII) by catalytic debenzylation affords glutaurine.
📌 参考资料/链接：
参考文献标题:Method of preparing gamma-L-glutamyl taurine
文献作者:Feuer,L.; et al.(Chinoin Pharmaceutical and Chemical Works Co.,Ltd.)
参考来源:US 4110441
📄 详细内容
合成路线:N-carbobenzyloxy-L-glutamic acid (I) is converted to the anhydride (II).Reaction of (II) with benzyl alcohol gives a mixture of half esters from which the halt ester (III) is isolated as the dicyclohexylamine salt.(III) is esterified with 4-nitrophenol (IV) with the aid of dicyclohexyl carbodiimide and the product (V) is reacted with taurine (VI).Deprotection of the resulting peptide (VII) by catalytic debenzylation affords glutaurine.
参考文献标题:Glutaurine
文献作者:N骻r醖i,M.
参考来源:Drugs Fut 1984,9(2),110
产品链接: CAS No. 56488-60-9››