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项目整合精选>>>Fludarabine phosphate, SHT-586, NSC-312887, 2-F-ara-AMP, 2-Fluoro-ara-AMP, Beneflur, Fludara
Fludarabine phosphate, SHT-586, NSC-312887, 2-F-ara-AMP, 2-Fluoro-ara-AMP, Beneflur, Fludara
磷酸氟达拉滨Chemical Name: 2-Fluoro-9-(5-O-phosphono-beta-D-arabinofuranosyl)-9H-purin-6-amine; 9-(beta-D-Arabinofuranosyl)-2-fluoroadenine 5'-(dihydrogen phosphate)
CAS No. 75607-67-9
项目整合开发状态: Launched-1991
项目研究机构: Berlex (Orphan Drug), Berlex (Originator), National Cancer Institute (Originator), Nihon Schering (Originator), Schering AG (Originator), Triton Biosciences (Licensee)
合成路线:The reaction of 9-beta-D-arabinofuranosyl-2-fluoroadenine (I) with triethyl phosphate and POCl3 gives 9-beta-D-arabinofuranosyl-2-fluoroadenine-5'-(diethylphosphate) (II),which is hydrolyzed with Domez 1x8 (formated form) resin.
📌 参考资料/链接：
参考文献标题:Prodrug derivatives of 9-beta-D-arabinofuranosyl-2-fluoroadenine
文献作者:Montgomery,J.A.; Shortnacy,A.T.(US Department of Health & Human Services)
参考来源:US 4357324
📄 详细内容
合成路线:The reaction of 9-beta-D-arabinofuranosyl-2-fluoroadenine (I) with triethyl phosphate and POCl3 gives 9-beta-D-arabinofuranosyl-2-fluoroadenine-5'-(diethylphosphate) (II),which is hydrolyzed with Domez 1x8 (formated form) resin.
参考文献标题:Fludarabine phosphate
文献作者:Serradell,M.N.; Castar,J.; Hopkins,S.J.
参考来源:Drugs Fut 1985,10(1),20
产品链接: CAS No. 75607-67-9››