项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
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项目整合精选

Lomerizine hydrochloride, DE-090, KB-2796, Terranas, Migsis

盐酸洛美利嗪洛美利嗪 Chemical Name: 1-[Bis(4-fluorophenyl)methyl]-4-(2,3,4-trimethoxy-benzyl)piperazine dihydrochloride
CAS No. 101477-54-7, 101477-55-8 (free base)
项目整合开发状态: Launched-1999
项目研究机构: Ni...
参考文献标题:1-(2,3,4-Tri-methoxybenzyl)-4[bis(4-fluorophenyl)m
文献作者:Ito,K.; Kanazawa,T.; Ohtaka,H.; Tsukamoto,G.(Kanebo Pharmaceuticals,Ltd.)
参考来源:EP 0159566; ES 8702393; ES 8801236; ES 8801237; JP 1985222472; US 4663325

Lofepramine hydrochloride, Gamanil, Gamonil

盐酸洛非帕明洛非帕明 Chemical Name: 1-(4-Chlorophenyl)-2-[3-(10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propylmethylamino]ethanone monohydrochloride
CAS No. 26786-32-3, 23047-25-8 (free base)
项目整合开发状态: Laun...
参考文献标题:Lofepramine
文献作者:Castar,J.; Arrigoni-Martelli,E.
参考来源:Drugs Fut 1976,1(3),129

Tertatolol hydrochloride, SE-2395, Prenalex, Artexal, Artex

盐酸特他洛尔特他洛尔 Chemical Name: (?-1-[(3,4-Dihydro-2H-1-benzothiopyran-8-yl)oxy]-3-[(1,1-dimethylethyl)amino]-2-propanol hydrochloride
CAS No. 33580-30-2, 34784-64-0 (free base)
项目整合开发状态: Launched-19...
参考文献标题:Tertatolol hydrochloride
文献作者:Leclerc,G.
参考来源:Drugs Fut 1986,11(2),131

Terazosin hydrochloride, MY-208, A-45975, ABT-975, Abbott-45975, Hytrin, Hytrine, Flotrin, Zayasel, Magnurol, Heitrin, Urodie, Hytracin, Vasomet, Hytrin BPH, Vasocard

盐酸特拉唑嗪二水物 1-(4-氨基-6,7-二甲氧基-2-喹唑啉基)4-[((四氢-2-呋喃基)羰基]哌嗪盐酸盐特拉唑嗪Chemical Name: 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbonyl]piperazine monohydrochloride dihydrate
CAS No...
参考文献标题:Antihypertensive agents
文献作者:Winn,M.; Kyncl,J.; Dunnigan,D.A.; Jones,P.H.(Abbott Laboratories Inc.)
参考来源:CA 1057754; CH 602712; DE 2646186; FR 2327787; GB 1517403; JP 52048678; US 4026894; US 4112097

Terbinafine hydrochloride, SF-86327, Lamisil AT, Daskil, Afogan, Lamisil

盐酸特比萘芬特比萘芬 Chemical Name: (E)-N-(6,6-Dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphthalenemethanamine hydrochloride; trans-N-Methyl-N-(1-naphthylmethyl)-6,6-dimethylhept-2-en-4-ynylamine hydrochloride 参考文献标题:Propenylamines,pharmaceutical compositions containing them and their use as pharmaceuticals
文献作者:Stz,A.(Novartis AG)
参考来源:EP 0024587; JP 56032440; JP 63313753; Us 4755534

Ciprofloxacin hydrochloride, Bay-o-9867 monohydrate, Septocipro, Ciprenit, Velmonit, Cipro XR, Ciproxan, Sarf, Cetraxal, Ciprobay, Ciloxan, Ciflox, Cipro, Eni, Ciproxin, Oftacilox

盐酸环丙沙星环丙沙星 Chemical Name: 1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid hydrochloride hydrate
CAS No. 86393-32-0, 85721-33-1 (free base, anhydrous)
项目整合开...
参考文献标题:1-Cyclopropyl-6-fluoro-1,4-dihidro-4-oxo-7-piperazino-quinoline-3-carboxilic acids,process for their preparation and antibacterial agents containing them
文献作者:Grohe,K.; Zeiler,H.J.; Metzger,K.G.(Bayer AG)
参考来源:EP 0078362; JP 4253963; JP 58074667

Revaprazan hydrochloride, SB-641257A, YH-1885

盐酸瑞伐拉赞盐酸瑞伐拉赞 Chemical Name: N-(4-Fluorophenyl)-4,5-dimethyl-6-(1-methyl-1,2,3,4-tetrahydroisoquinolin-2-yl)pyrimidin-2-amine hydrochloride; N-[4,5-Dimethyl-6-(1-methyl-1,2,3,4-tetrahydroisoquinolin-2...
参考文献标题:Quinazoline derivs.
文献作者:Lee,J.W.; Chae,J.S.; Kim,C.S.; Kim,J.K.; Lim,D.S.; Shon,M.K.; Jo,D.W.(Yuhan Corp.)
参考来源:EP 0677049; WO 9414795

Tiapride hydrochloride, Gramalil, Tiapridal

盐酸硫必利泰必利 Chemical Name: N-[2-(Diethylamino)ethyl]-2-methoxy-5-(methylsulfonyl)benzamide hydrochloride
CAS No. 51012-33-0, 51012-32-9 (free base)
项目整合开发状态: Launched-1976
项目研究机构: Sanofi-Aventi...
参考文献标题:Tiapride
文献作者:Neuman,M.; Prous,J.R.
参考来源:Drugs Fut 1976,1(2),88

Mianserin hydrochloride, Tetramide, Lantanon, Tolvin, Athymil, Tolvon, Lerivon, Bolvidon

盐酸米安色林米安舍林 Chemical Name: 2-Methyl-1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine hydrochloride
CAS No. 21535-47-7, 24219-97-4 (free base)
项目整合开发状态: Launched-1975
项目研究机构: Nippon ...
参考文献标题:Polycyclic piperazines
文献作者:van der Burg,W.J.; Delobelle,J.
参考来源:US 3534041

Mitozantrone hydrochloride, Mitoxantrone hydrochloride, DAD, NSC-301739, CL-232315, Onkotrone, Novantrone, Novantron

盐酸米托蒽醌米托蒽醌 Chemical Name: 1,4-Dihydroxy-5,8-bis[2-(2-hydroxyethylamino)ethylamino]-9,10-anthracenedione dihydrochloride
CAS No. 70476-82-3, 65271-80-9 (free base)
项目整合开发状态: Launched-1984
项目研...
参考文献标题:CL-232315
文献作者:Blancafort,P.; Sweetman,A.J.; Castar,J.; Serradell,M.N.
参考来源:Drugs Fut 1980,5(5),234