Lofepramine hydrochloride, Gamanil, Gamonil
盐酸洛非帕明 洛非帕明 Chemical Name: 1-(4-Chlorophenyl)-2-[3-(10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propylmethylamino]ethanone monohydrochloride
CAS No. 26786-32-3, 23047-25-8 (free base)
项目整合开发状态: Launched-1980
项目研究机构: Merck & Co. (Originator), Merck KGaA (Originator)
合成路线:By condensation of N-methyl-3-(10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propylamine (desipramine) (I) with 4-chlorophenacyl chloride (II) by means of NaHCO3 in benzene-water.
📌 参考资料/链接：
参考文献标题:Lofepramine
文献作者:Castar,J.; Arrigoni-Martelli,E.
参考来源:Drugs Fut 1976,1(3),129
📄 详细内容
合成路线:By condensation of N-methyl-3-(10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propylamine (desipramine) (I) with 4-chlorophenacyl chloride (II) by means of NaHCO3 in benzene-water.
参考文献标题:Chemistry and pharmacology of a new potential antidepressant
文献作者:Eriksoo,E.; Rohte,O.
参考来源:Arzneim-Forsch Drug Res 1970,20(10),1561
产品链接: CAS No. 26786-32-3›› 产品链接: CAS No.23047-25-8››