Lomerizine hydrochloride, DE-090, KB-2796, Terranas, Migsis
盐酸洛美利嗪 洛美利嗪 Chemical Name: 1-[Bis(4-fluorophenyl)methyl]-4-(2,3,4-trimethoxy-benzyl)piperazine dihydrochloride
CAS No. 101477-54-7, 101477-55-8 (free base)
项目整合开发状态: Launched-1999
项目研究机构: Nippon Organon (Originator), Pfizer (Licensee), Santen (Licensee)
合成路线:By reductocondensation of 2,3,4-trimethoxybenzaldehyde (I) with l-[bis(4-fluorophenyl)methyl] piperazine (II) by means of formic acid at 100-120 C.
📌 参考资料/链接：
参考文献标题:1-(2,3,4-Tri-methoxybenzyl)-4[bis(4-fluorophenyl)m
文献作者:Ito,K.; Kanazawa,T.; Ohtaka,H.; Tsukamoto,G.(Kanebo Pharmaceuticals,Ltd.)
参考来源:EP 0159566; ES 8702393; ES 8801236; ES 8801237; JP 1985222472; US 4663325
📄 详细内容
合成路线:By reductocondensation of 2,3,4-trimethoxybenzaldehyde (I) with l-[bis(4-fluorophenyl)methyl] piperazine (II) by means of formic acid at 100-120 C.
参考文献标题:KB-2796
文献作者:Prous,J.; Castar,J.
参考来源:Drugs Fut 1988,13(4),312
合成路线:By reductocondensation of 2,3,4-trimethoxybenzaldehyde (I) with l-[bis(4-fluorophenyl)methyl] piperazine (II) by means of formic acid at 100-120 C.
参考文献标题:Benzylpiperazine derivatives.IV.Synthesis and ce
文献作者:Kanazawa,T.; Ohtaka,H.; Ito,K.; Stukamoto,G.
参考来源:Chem Pharm Bull 1987,35(8),3270
产品链接: CAS No. 101477-54-7›› 产品链接: CAS No.101477-55-8››