Tiapride hydrochloride, Gramalil, Tiapridal
盐酸硫必利 泰必利 Chemical Name: N-[2-(Diethylamino)ethyl]-2-methoxy-5-(methylsulfonyl)benzamide hydrochloride
CAS No. 51012-33-0, 51012-32-9 (free base)
项目整合开发状态: Launched-1976
项目研究机构: Sanofi-Aventis (Originator), Fujisawa (Licensee)
合成路线:Prepared by reacting 2-methoxy-5-methylsulfonylbenzoic acid (I) with isobutyl chloroformate (A) in dioxane to give the corresponding anhydride (II),which is finally condensed with N,N-diethylethylenediamine (B).
📌 参考资料/链接：
参考文献标题:Tiapride
文献作者:Neuman,M.; Prous,J.R.
参考来源:Drugs Fut 1976,1(2),88
📄 详细内容
合成路线:Prepared by reacting 2-methoxy-5-methylsulfonylbenzoic acid (I) with isobutyl chloroformate (A) in dioxane to give the corresponding anhydride (II),which is finally condensed with N,N-diethylethylenediamine (B).
参考文献标题:Process for preparing benzamides
文献作者:Bulteau,G.; Acher,J.
参考来源:CH 585699; DE 2327192; GB 1394563; JP 49085037
产品链接: CAS No. 51012-33-0›› 产品链接: CAS No.51012-32-9››