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项目整合精选>>>Terazosin hydrochloride, MY-208, A-45975, ABT-975, Abbott-45975, Hytrin, Hytrine, Flotrin, Zayasel, Magnurol, Heitrin, Urodie, Hytracin, Vasomet, Hytrin BPH, Vasocard
Terazosin hydrochloride, MY-208, A-45975, ABT-975, Abbott-45975, Hytrin, Hytrine, Flotrin, Zayasel, Magnurol, Heitrin, Urodie, Hytracin, Vasomet, Hytrin BPH, Vasocard
盐酸特拉唑嗪二水物 1-(4-氨基-6,7-二甲氧基-2-喹唑啉基)4-[((四氢-2-呋喃基)羰基]哌嗪盐酸盐 特拉唑嗪Chemical Name: 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbonyl]piperazine monohydrochloride dihydrate
CAS No. 70024-40-7, 63074-08-8 (anhydrous), 63590-64-7 (free base, anhydrous)
项目整合开发状态: Launched-1985
项目研究机构: Abbott (Originator), Dainippon Pharmaceutical (Not Determined), Nikken Chemicals (Not Determined), Esteve (Licensee), Salvat (Licensee)
合成路线:The reaction of furoyl chloride (I) with piperazine (II) by means of NaOH in water gives N-(2-furoyl)piperazin (III),which is reduced with H2 over Raney-Ni in methanol to afford N-(tetrahydro-2-furoyl)piperazine (IV) .Finally,this compound is condensed with 2-chloro-4-amino-6,7-dimethoxyquinazoline (V) in refluxing methoxyethanol.
📌 参考资料/链接：
参考文献标题:Antihypertensive agents
文献作者:Winn,M.; Kyncl,J.; Dunnigan,D.A.; Jones,P.H.(Abbott Laboratories Inc.)
参考来源:CA 1057754; CH 602712; DE 2646186; FR 2327787; GB 1517403; JP 52048678; US 4026894; US 4112097
📄 详细内容
合成路线:The reaction of furoyl chloride (I) with piperazine (II) by means of NaOH in water gives N-(2-furoyl)piperazin (III),which is reduced with H2 over Raney-Ni in methanol to afford N-(tetrahydro-2-furoyl)piperazine (IV) .Finally,this compound is condensed with 2-chloro-4-amino-6,7-dimethoxyquinazoline (V) in refluxing methoxyethanol.
参考文献标题:1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-tetrahydrofuroyl)piperazine hydrochloride dihydrate
文献作者:Roteman,R.(Abbott Laboratories Inc.)
参考来源:CA 1081229; DE 2831112; FR 2399430; JP 54027588
合成路线:The reaction of furoyl chloride (I) with piperazine (II) by means of NaOH in water gives N-(2-furoyl)piperazin (III),which is reduced with H2 over Raney-Ni in methanol to afford N-(tetrahydro-2-furoyl)piperazine (IV) .Finally,this compound is condensed with 2-chloro-4-amino-6,7-dimethoxyquinazoline (V) in refluxing methoxyethanol.
参考文献标题:Terazosin Hydrochloride
文献作者:Thorpe,P.; Castar,J.; Serradell,M.N.; Blancafort,P.
参考来源:Drugs Fut 1983,8(1),45