项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
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项目整合精选

Sarpicillin, BL-P1761

沙匹西林Chemical Name: 6-(2,2-Dimethyl-5-oxo-4-phenyl-1-imidazolidinyl)penicillanic acid methoxymethyl ester; (2S,5R,6R)-6-(2,2-Dimethyl-5-oxo-4-phenyl-1-imidazolidinyl)-3,3-dimethyl-7-oxo-4-thia-1-azabic...
参考文献标题:Antibacterial agents
文献作者:Sleezer,P.D.; Johnson,D.A.(Bristol-Myers Squibb Co.)
参考来源:DE 2244915; ES 406644; FR 2154488; GB 1400584; JP 48036186

Saframycin A

沙弗拉霉素 AChemical Name: N-[(6S,7R,9R,14aS,15R)-7-Cyano-1,5,6,7,9,10,13,14,14a,15-decahydro-2,11-dimethoxy-3,12,16-trimethyl-1,4,10,13-tetraoxo-6,15-imino-4H-isoquino[3,2-b][3]benzazocin-9-ylmethyl]-2-ox...
参考文献标题:A concise,stereocontrolled synthesis of (-) saframycin A by the directed condensation of alpha-amino aldehyde
文献作者:Kung,D.W.; Myers,A.G.
参考来源:J Am Chem Soc 1999,121(46),10828

Saprisartan, GR-138950C(K salt), GR-138950X, GR-138950

沙普立沙坦 [2-[3-溴-5-[(5-氨基甲酰-4-环丙基-2-乙基咪唑-1-基)甲基]-1-苯并呋喃-2-基]苯基]-(三氟甲基磺酰基)亚胺钾 Chemical Name: 1-[3-Bromo-2-[2-(trifluoromethylsulfonamido)phenyl]benzofuran-5-ylmethyl]-4-cyclopropyl-2-ethyl-1H-imidazole-5-...
参考文献标题:1H-Imidazol-1-yl-methyl benzofuran derivs.with the imidazolyl moiety being substd.by a cycloalkyl group
文献作者:Ross,B.C.; Middlemiss,D.; Scopes,D.I.C.; Jack,T.I.M.; Cardwell,K.S.; Dowle,M.D.; Judd,D.B.; Watson,S.P.(Glaxo Wellcome plc)
参考来源:EP 0514198; JP 1994211846; US 5498722; WO 9220674

Satranidazole, Go-10213, C-10213-Go

沙曲硝唑Chemical Name: 1-Methanesulfonyl-3-(1-methyl-5-nitroimidazol-2-yl)-2-imidazolidinone; 1-(1-Methyl-5-nitro-1H-imidazol-2-yl)-3-(methylsulfonyl)-2-imidazolidinone
CAS No. 56302-13-7
项目整合开发状态: ...
参考文献标题:Satranidazole
文献作者:Arya,V.P.
参考来源:Drugs Fut 1983,8(9),797

Satigrel, E-5510

沙替格雷Chemical Name: 4-Cyano-5,5-bis(4-methoxyphenyl)-4-pentenoic acid
CAS No. 111753-73-2
项目整合开发状态: Phase III
项目研究机构: Eisai (Originator)
合成路线:The condensation of 4,4'-dimethoxybenzophenone ...
参考文献标题:Diphenyl-methane derivative,pharmaceutical composition and use
文献作者:Yamagishi,Y.; Akasaka,K.; Suzuki,T.; Miyamoto,M.; Nakamoto,K.; Okano,K.; Abe,S.; Ikuta,H.; Hayashi,K.; Yoshimura,H.; Fujimori,T.; Harada,K.; Yamatsu,I.(Eisai Co.,Ltd.)
参考来源:AU 8770085; EP 0238973; JP 87223164; JP 88010743

Saterinone, BDF-8634

沙特力农Chemical Name: 1-[4-(3-Cyano-1,2-dihydro-6-methyl-2-oxopyridin-5-yl)phenoxy]-3-[4-(2-methoxyphenyl)piperazin-1-yl]-2-propanol
CAS No. 102669-89-6
项目整合开发状态: Phase II
项目研究机构: Beiersdorf (Or...
参考文献标题:Phenylpiperazinylpropanol derivs.
文献作者:(Beiersdorf-Lilly GmbH)
参考来源:DE 3424685; EP 0167121; ES 8608511; JP 1986030573; US 4631279; US 4631281

Saredutant, SR-489686, SR-48965 (R-isomer), SR-48968

沙瑞度坦Chemical Name: (S)-N-[4-(4-Acetamido-4-phenylpiperidin-1-yl)-2-(3,4-dichlorophenyl)butyl]-N-methylbenzamide
CAS No. 142001-63-6
项目整合开发状态: Phase II
项目研究机构: Sanofi-Aventis (Originator)
合...
参考文献标题:Arylalkylamines,process for their preparation and pharmaceutical compsns.containing them
文献作者:Emonds-Alt,X.; Goulaouic,P.; Proietto,V.; Van Broeck,D.(Sanofi-Synthabo)
参考来源:EP 0474561; FR 2666335; FR 2678267; JP 1992261155; US 5236921; US 5350852

Safinamide mesilate, FCE-28073(R-isomer), PNU-151774E, NW-1015, FCE-26743

沙芬酰胺甲磺酸盐沙芬酰胺 Chemical Name: 2(S)-[4-(3-Fluorobenzyloxy)benzylamino]propionamide methanesulfonate
CAS No. 202825-46-5, 133865-89-1 (free base)
项目整合开发状态: Phase III
项目研究机构: Newron (Originator)...
参考文献标题:N-Phenylalkyl substd.alpha-amino carboxamide derivs.and process for their preparation
文献作者:Dostert,P.; Pevarello,P.; Heidempergher,F.; Varasi,M.; Bonsignori,A.; Roncucci,R.(Pharmacia Corp.)
参考来源:EP 0400495; EP 0426816; JP 1992500215; US 5236957; US 5391577; US 5502079; WO 9014334

Sarmoxicillin

沙莫西林Chemical Name: (2S,5R,6R)-6-[4-(4-Hydroxyphenyl)-2,2-dimethyl-5-oxoimidazolidin-1-yl]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid methoxymethyl ester
CAS No. 67337-44...
参考文献标题:
文献作者:
参考来源:BE 831941; JP 7723089

Tomelukast, LY-171883

油酸三乙醇胺Chemical Name: 1-[2-Hydroxy-3-propyl-4-[4-(1H-tetrazol-5-yl)butoxy]phenyl]ethanone; 5-[4-(4-Acetyl-3-hydroxy-2-propylphenoxy)butyl]tetrazole
CAS No. 88107-10-2
项目整合开发状态: Phase III
项目研究机...
参考文献标题:Leukotriene antagonists
文献作者:Marshall,W.S.; Verge,J.P.(Eli Lilly and Company)
参考来源:EP 0108592