Safinamide mesilate, FCE-28073(R-isomer), PNU-151774E, NW-1015, FCE-26743
沙芬酰胺甲磺酸盐 沙芬酰胺 Chemical Name: 2(S)-[4-(3-Fluorobenzyloxy)benzylamino]propionamide methanesulfonate
CAS No. 202825-46-5, 133865-89-1 (free base)
项目整合开发状态: Phase III
项目研究机构: Newron (Originator)
合成路线:Safinamide has been obtained by reductocondensation of 4-(3-fluorobenzyloxy)benzaldehyde (I) with L-alaninamide (II) by means of sodium cyanoborohydride in methanol.
📌 参考资料/链接：
参考文献标题:N-Phenylalkyl substd.alpha-amino carboxamide derivs.and process for their preparation
文献作者:Dostert,P.; Pevarello,P.; Heidempergher,F.; Varasi,M.; Bonsignori,A.; Roncucci,R.(Pharmacia Corp.)
参考来源:EP 0400495; EP 0426816; JP 1992500215; US 5236957; US 5391577; US 5502079; WO 9014334
📄 详细内容
合成路线:Safinamide has been obtained by reductocondensation of 4-(3-fluorobenzyloxy)benzaldehyde (I) with L-alaninamide (II) by means of sodium cyanoborohydride in methanol.
参考文献标题:Synthesis and anticonvulsant activity of new benzyloxybenzylacetamide derivatives
文献作者:Dostert,P.; Pevarello,P.; Bonsignori,A.; Varasi,M.
参考来源:12th Int Symp Med Chem (Sept 13-17,Basel) 1992,Abst P-089.C
合成路线:Safinamide has been obtained by reductocondensation of 4-(3-fluorobenzyloxy)benzaldehyde (I) with L-alaninamide (II) by means of sodium cyanoborohydride in methanol.
参考文献标题:Synthesis and anticonvulsant activity of a new class of 2-[arylalkyl)amino]alkanamide derivatives
文献作者:Pevarello,P.; Bonsignori,A.; Dostert,P.; Heidempergher,F.; Pinciroli,V.; Colombo,M.; McArthur,R.A.; Salvati,P.; Post,C.; Fariello,R.G.; Varasi,M.
参考来源:J Med Chem 1998,41(4),579
合成路线:Safinamide has been obtained by reductocondensation of 4-(3-fluorobenzyloxy)benzaldehyde (I) with L-alaninamide (II) by means of sodium cyanoborohydride in methanol.
参考文献标题:Safinamide mesilate
文献作者:Sorbera,L.A.; Castar,J.; Leeson,P.A.
参考来源:Drugs Fut 2001,26(8),745
产品链接: CAS No. 202825-46-5›› 产品链接: CAS No.133865-89-1››