Satigrel, E-5510
沙替格雷Chemical Name: 4-Cyano-5,5-bis(4-methoxyphenyl)-4-pentenoic acid
CAS No. 111753-73-2
项目整合开发状态: Phase III
项目研究机构: Eisai (Originator)
合成路线:The condensation of 4,4'-dimethoxybenzophenone (I) with ethyl 4-bromo-4-cyanobutyrate (II) by means of trimethyl borate,Zn and I2 in THF gives ethyl 4-cyano-5,5-bis(4-methoxyphenyl)-4-pentenoate (III),which is saponified with NaOH in hot dioxane-water.
📌 参考资料/链接：
参考文献标题:Diphenyl-methane derivative,pharmaceutical composition and use
文献作者:Yamagishi,Y.; Akasaka,K.; Suzuki,T.; Miyamoto,M.; Nakamoto,K.; Okano,K.; Abe,S.; Ikuta,H.; Hayashi,K.; Yoshimura,H.; Fujimori,T.; Harada,K.; Yamatsu,I.(Eisai Co.,Ltd.)
参考来源:AU 8770085; EP 0238973; JP 87223164; JP 88010743
📄 详细内容
合成路线:The condensation of 4,4'-dimethoxybenzophenone (I) with ethyl 4-bromo-4-cyanobutyrate (II) by means of trimethyl borate,Zn and I2 in THF gives ethyl 4-cyano-5,5-bis(4-methoxyphenyl)-4-pentenoate (III),which is saponified with NaOH in hot dioxane-water.
参考文献标题:E-5510
文献作者:Prous,J.; Castar,J.
参考来源:Drugs Fut 1989,14(3),215
产品链接: CAS No. 111753-73-2››