Sarpicillin, BL-P1761
沙匹西林Chemical Name: 6-(2,2-Dimethyl-5-oxo-4-phenyl-1-imidazolidinyl)penicillanic acid methoxymethyl ester; (2S,5R,6R)-6-(2,2-Dimethyl-5-oxo-4-phenyl-1-imidazolidinyl)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid methoxymethyl ester
CAS No. 40966-79-8
项目整合开发状态: Biological Testing
项目研究机构: Bristol-Myers Squibb (Originator)
合成路线:The esterification of potassium phenoxymethylpenicillanate (I) with chloromethyl methyl ether (A) in methylene chloride-THF gives the methoxymethyl ester of penicilline V (II),which is then treated with dimethylaniline (B) in CH2Cl2 to afford methoxymethyl 6-aminopenicillanate (III).Finally,this product is condensed with phenylglycyl chloride (C) hydrochloride and acetone (D) by means of NaOH.
📌 参考资料/链接：
参考文献标题:Antibacterial agents
文献作者:Sleezer,P.D.; Johnson,D.A.(Bristol-Myers Squibb Co.)
参考来源:DE 2244915; ES 406644; FR 2154488; GB 1400584; JP 48036186
📄 详细内容
合成路线:The esterification of potassium phenoxymethylpenicillanate (I) with chloromethyl methyl ether (A) in methylene chloride-THF gives the methoxymethyl ester of penicilline V (II),which is then treated with dimethylaniline (B) in CH2Cl2 to afford methoxymethyl 6-aminopenicillanate (III).Finally,this product is condensed with phenylglycyl chloride (C) hydrochloride and acetone (D) by means of NaOH.
参考文献标题:Sarpicillin
文献作者:Playle,A.C.; Castar,J.
参考来源:Drugs Fut 1977,2(7),478
产品链接: CAS No. 40966-79-8››