Satranidazole, Go-10213, C-10213-Go

沙曲硝唑Chemical Name: 1-Methanesulfonyl-3-(1-methyl-5-nitroimidazol-2-yl)-2-imidazolidinone; 1-(1-Methyl-5-nitro-1H-imidazol-2-yl)-3-(methylsulfonyl)-2-imidazolidinone
CAS No. 56302-13-7
项目整合开发状态: Biological Testing
项目研究机构: Novartis (Originator)
合成路线:C-10213-Go has been synthesized from 1-methyl-2-mercaptoimidazole (I).When (I) is methylated with methyl iodide it gives the corresponding thiomethyl derivative (II).Nitration of (II) yields the nitro derivative (III).Oxidation of (III) with monoperphthalic acid gives the sulfone (IV).Condensation of (IV) with 1-methanesulfonyl-2-imidazolidinone (VI) in the presence of sodium hydride affords C-10213-Go.