合成路线:A suspension of potassium phenoxymethylpenicillanate (I) in CH2Cl2 is treated with bromomethyl methyl ether (II) and DMF to give methoxymethyl ester of penicilline V (phenoxymethylpenicillanic acid) (III),which by treatment with PCl5 and dimethylaniline in CH2Cl2 is converted into methoxymethyl 6-aminopenicillanate (IV).The condensation of (IV) with p-hydroxyphenylglycyl chloride (V) by means of triethylamine in CH2Cl2 affords amoxicilline methoxymethyl ester (VI),which is finally treated with acetone at pH 6.5-9.5.
参考文献标题:
文献作者:Sleezer,P.; Jonhson,D.A.
参考来源:ZA 7504722
合成路线:A suspension of potassium phenoxymethylpenicillanate (I) in CH2Cl2 is treated with bromomethyl methyl ether (II) and DMF to give methoxymethyl ester of penicilline V (phenoxymethylpenicillanic acid) (III),which by treatment with PCl5 and dimethylaniline in CH2Cl2 is converted into methoxymethyl 6-aminopenicillanate (IV).The condensation of (IV) with p-hydroxyphenylglycyl chloride (V) by means of triethylamine in CH2Cl2 affords amoxicilline methoxymethyl ester (VI),which is finally treated with acetone at pH 6.5-9.5.
参考文献标题:Sarmoxicillin
文献作者:Blancafort,P.; Serradell,M.N.; Castar,J.; Mealy,N.
参考来源:Drugs Fut
产品链接: CAS No. 67337-44-4››