项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
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项目整合精选

Cefotiam cilexetil, Cefotiam hexetil, SCE-2174, Pansporin T

头孢替安Chemical Name: (6R,7R)-7-[2-(2-Amino-4-thiazolyl)acetamido]-3-[[[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl]thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 1-(cyclohexylo...
参考文献标题:Antibacterial solid compsn.for oral administratio
文献作者:Hirai,S.; Koyama,H.; Makino,T.(Takeda Chemical Industries,Ltd.)
参考来源:EP 0163433; JP 1985233012; JP 1987030713

Cefmatilen hydrochloride hydrate, S-1090

头孢替林β.-L-来苏-六吡喃糖,1,3,6-三脱氧-1,6-环磺酰-2-O-甲基-4-O-(苯基甲基)-Chemical Name: (-)-(6R,7R)-7-[2-(2-Aminothiazol-4-yl)-2(Z)-(hydroxyimino)acetamido]-3-(1H-1,2,3-triazol-4-ylsulfanylmethylsulfanyl)-3-cephem-4-carb...
参考文献标题:Thioalkylthio cephalosporin derivs
文献作者:Kubota,T.; Kume,M.(Shionogi & Co.Ltd.)
参考来源:EP 0467647; JP 1992234346; JP 1993059066; US 5214037

Cefpodoxime proxetil, RU-51807, U-76252, CS-807, Otreon, Vantin, Doxef, Orelox, Podomexef, Banan

头孢泊肟酯Chemical Name: (6R,7R)-7-[2-(2-Amino-4-thiazolyl)-2(Z)-(methoxyimino)acetamido]-3-(methoxymethyl)-3-cephem-4-carboxylic acid 1-(isopropoxycarbonyloxy)ethyl ester; [6R-(6alpha,7beta(Z)]-7-[(2-Amin...
参考文献标题:Process for preparing 3-alkoxymethylcephalosporin derivatives
文献作者:Fujimoto,K.; Nakayama,E.; Nakao,H.(Sankyo Co.,Ltd.)
参考来源:DE 3244457

Cefteram, T-2525

头孢特仑新戊酯Chemical Name: [6R-[6alpha,7beta(Z)]]-7-[2-(2-Aminothiazol-4-yl)-2-(methoxyimino)acetamido]-3-(5-methyl-2H-tetrazol-2-ylmethyl)-3-cephem-4-carboxylic acid
CAS No. 82547-58-8
项目整合开发状态: Pha...
参考文献标题:Cephalosporins
文献作者:Hirakawa,T.; Imaizumi,H.; Inaba,T.; Konishi,Y.; Narita,H.; Sadaki,H.; Saikawa,I.; Tai,M.; Taki,H.; Watanabe,Y.(Toyama Chemical Co.,Ltd.)
参考来源:AU 8549860; AU 8549863; DE 3137854; US 4489072

Cefprenam, Cefluprenam, E-1077

头孢瑞南Chemical Name: (-)-(6R,7R)-7-[2-(5-Amino-1,2,4-thiadiazol-3-yl)-2(Z)-(fluoromethoxyimino)acetamido]-3-[3-[(carbamoylmethyl)ethylmethylammonio]-1(E)-propenyl]-3-cephem-4-carboxylate; [6R-[3(E),6alp...
参考文献标题:3-Propenylcephem derivs.,preparation thereof,chemical intermediates therein,pharmaceutical compsn.and use
文献作者:Kamiya,T.; Naito,T.; Negi,S.; Komatu,Y.; Kai,Y.; Nakamura,T.; Sugiyama,I.; Machida,Y.; Nomoto,S.; Kitoh,K.; Katsu,K.; Yamauchi,H.(Eisai Co.,Ltd.)
参考来源:AU 8779577; EP 0264091; JP 1989156983; JP 1989156984; US 4921850; US 5089491

Cefoxitin, Mefoxitin, Mefoxin

头孢西丁Chemical Name: 3-Carbamoyloxymethyl-7alpha-methoxy-7beta-(2-thienylacetamido)-3-cephem-4-carboxylic acid sodium salt
CAS No. 35607-66-0 (free acid)
项目整合开发状态: Launched-1977
项目研究机构: Merck S...
参考文献标题:Antibiotics and processes for their production
文献作者:Christensen,B.G.; Cama,L.D.(Merck & Co.,Inc.)
参考来源:DE 2203653; FR 2161866; GB 1350772

Nepinalone, Tussolvina(hydrochloride)

奈哌那隆Chemical Name: (?-1-Methyl-1-(2-piperidinoethyl)-1,2,3,4-tetrahydro-2-naphthalenone
CAS No. 22443-11-4
项目整合开发状态: Launched-1994
项目研究机构: Pfizer (Originator)
合成路线:Friedel-Crafts condensat...
参考文献标题:Novel 1,2,3,4-tetrahydronaphthalen-2-ones and a process for the preparation thereof
文献作者:Fusco,R.; Tenconi,F.(Pfizer Inc.)
参考来源:GB 1140990; US 3576811

Nedocromil sodium, FPL-59002KP, FPL-59002(free acid), Tilavist, Tilarin, Alocril, Abrevia(former Brand Name), Rapitil, Tilade

奈多罗米钠奈多罗米 Chemical Name: Disodium 9-ethyl-6,9-dihydro-4,6-dioxo-10-propyl-4H-pyrano[3,2-g]quinoline-2,8-dicarboxylate
CAS No. 69049-74-7, 69049-73-6 (free acid)
项目整合开发状态: Launched-1986
项目研究机...
参考文献标题:Nouvelles pyranoquinol閕nones et leurs compositions pharmaceutiques
文献作者:Caims,H.; Cox,D.(Rh鬾e-Poulenc Rorer Ltd.)
参考来源:DE 2819215; ES 469391; JP 1199909; JP 53137969

Nelarabine, Nelzarabine, GW-506U78, GW-506U, 506U78, 506U

奈拉滨Chemical Name: 9-(beta-D-Arabinofuranosyl)-6-methoxy-9H-purin-2-amine; 9-beta-D-Arabinofuranosyl-6-O-methylguanine
CAS No. 121032-29-9
项目整合开发状态: Phase III
项目研究机构: GlaxoSmithKline (Originat...
参考文献标题:Antiviral cpds.
文献作者:Krenitsky,T.A.; Koszalka,G.W.; Jones,L.A.; Averett,D.R.; Moorman,A.R.(Glaxo Wellcome plc)
参考来源:AU 8816718; EP 0294114; JP 1988310831; US 5424295; US 5539098

Netilmicin sulfate, Sch-20569, Certomycin, Zetamicin, Netillin, Netromicine, Netromycin

奈替米星硫酸盐奈替米星 Chemical Name: O-3-Deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl-(1--6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-alpha-D-glycero-hex-4-enopyranosyl-(1--4)]-2-deoxy-N1-ethyl-D-streptam...
参考文献标题:Novel pseudotrisaccharides and methods for their production
文献作者:Daniels,P.J.L.; Testa,R.; Tattanahalli,L.; Mallams,A.K.; Wright,J.J.; Weinstein,M.J.; Wagman,G.H.(Schering Corp.)
参考来源:DE 2437160; FR 2240015; GB 1473733; US 4029882