Nelarabine, Nelzarabine, GW-506U78, GW-506U, 506U78, 506U

奈拉滨Chemical Name: 9-(beta-D-Arabinofuranosyl)-6-methoxy-9H-purin-2-amine; 9-beta-D-Arabinofuranosyl-6-O-methylguanine
CAS No. 121032-29-9
项目整合开发状态: Phase III
项目研究机构: GlaxoSmithKline (Originator)
合成路线:The reaction of 6-chloropurine-2-amine (I) with methanol and NaH gives 6-O-methylguanine (II),which is mixed with uracil arabinoside (III),purine nucleoside phosphorylase and uridine phosphorylase and submitted to incubation in a potassium phosphate solution at 37 C.After 26 days of incubation,the target compound is isolated.