Nepinalone, Tussolvina(hydrochloride)
奈哌那隆Chemical Name: (?-1-Methyl-1-(2-piperidinoethyl)-1,2,3,4-tetrahydro-2-naphthalenone
CAS No. 22443-11-4
项目整合开发状态: Launched-1994
项目研究机构: Pfizer (Originator)
合成路线:Friedel-Crafts condensation of 2-phenylpropionyl chloride (I) with ethylene in the presence of AlCl3 furnished 1-methyl-1,2,3,4-tetrahydronaphthalen-2-one (II) (1).Subsequent alkylation of the sodium enolate of (II) with N-(2-chloroethyl)piperidine (III) gave rise to the title compound.
📌 参考资料/链接：
参考文献标题:Novel 1,2,3,4-tetrahydronaphthalen-2-ones and a process for the preparation thereof
文献作者:Fusco,R.; Tenconi,F.(Pfizer Inc.)
参考来源:GB 1140990; US 3576811
📄 详细内容
合成路线:Friedel-Crafts condensation of 2-phenylpropionyl chloride (I) with ethylene in the presence of AlCl3 furnished 1-methyl-1,2,3,4-tetrahydronaphthalen-2-one (II) (1).Subsequent alkylation of the sodium enolate of (II) with N-(2-chloroethyl)piperidine (III) gave rise to the title compound.
参考文献标题:A process for the preparation of nepinalone
文献作者:Tenconi,F.; Furfaro,S.
参考来源:EP 0507001
产品链接: CAS No. 22443-11-4››