项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
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项目整合精选

Nebivolol, R-67145((-)-enantiomer), R-67138((+)-enantiomer), ME-3255, R-67555(hydrochloride), R-65824, Silostar, Lobivon, Nebilet(HCl)

奈比洛尔 (1S)-1-[(2S)-6-氟色满-2-基]-2-[[(2S)-2-[(2S)-6-氟色满-2-基]-2-羟基乙基]氨基]乙醇 (+)-奈必洛尔Chemical Name: (alphaR*,alpha'R*,2R*,2'S*)-alpha,alpha'-(Iminodimethylene)bis[6-fluoro-2-chromanmethanol]; [2R*[R*[R*(S*)]...
参考文献标题:NEBIVOLOL < Prop INN; USAN >
文献作者:Prous,J.; Castar,J.
参考来源:Drugs Fut 1989,14(10),957

Napsagatran, Ro-46-6240/010(monoH2O), Ro-46-6240

奈沙加群奈沙加群 Chemical Name: 2-[3-[N-[1-Amidinopiperidin-3(S)-ylmethyl]carbamoyl]-N-cyclopropyl-2(S)-(2-naphthylsulfonamido)propionamido]acetic acid; N-[N4-[1-Amidinopiperidin-3(S)-ylmethyl]-N2-(2-naphthy...
参考文献标题:Design and synthesis of potent and highly selective thrombin inhibitors
文献作者:Hilpert,K.; Ackermann,J.; Banner,D.W.; Gast,A.; Gubernator,K.; Hadvary,P.; Labler,L.; Muller,K.; Schmid,G.; Tschopp,T.B.; et al.
参考来源:J Med Chem 1994,37(23),3889-901

Nefazodone hydrochloride, MJ-13754-1, BMY-13754-1, Rulivan, Reseril, Menfazona, Nefadar, Dutonin, Serzone

奈法唑酮盐酸盐奈法唑酮 Chemical Name: 2-[3-[4-(3-Chlorophenyl)piperazin-1-yl]propyl]-5-ethyl-2,4-dihydro-4-(2-phenoxyethyl)-3H-1,2,4-triazol-3-one hydrochloride
CAS No. 82752-99-6, 83366-66-9 (free base)
...
参考文献标题:Nefazodone Hydochloride
文献作者:Eison,M.S.; Smith,D.W.; Madding,G.D.; Taylor,D.P.
参考来源:Drugs Fut 1987,12(8),758

Nerisopam, EGIS-6775, GYKI-52322

奈立索泮Chemical Name: 1-(4-Aminophenyl)-4-methyl-7,8-dimethoxy-5H-2,3-benzodiazepine
CAS No. 102771-12-0, 102771-15-3 (diHCl), 102771-14-2 (monoHCl), 102771-16-4 (sulfate)
项目整合开发状态: Phase I
项目研究...
参考文献标题:5H-2,3-Benzodiazepine derivs.and pharmaceutical c
文献作者:Lang,T.; Kori,J.; Andr醩i,F.; Botka,P.; H醡ori,T.; Berzsenyi,P.; Goldschmidt,K.; Z髄yomi,G.; Elekes,I.; L醤g,Z.(Egis Pharmaceuticals Ltd.)
参考来源:BE 0902953; CH 667090; DE 3527117; ES 8608494; FR 2568252; GB 2162184; JP 1986043174; US 4614740

Neridronate, Neridronic acid, AHHexBP, Nerixia

奈立膦酸Chemical Name: (6-Amino-1-hydroxyhexylidene)diphosphonic acid
CAS No. 79778-41-9
项目整合开发状态: Launched-2002
项目研究机构: Abiogen (Orphan Drug), Abiogen (Originator)
合成路线:The target product is ...
参考文献标题:Process for the preparation of diphosphonic acids and salts thereof
文献作者:Guainai-Ricci,G.; Rosini,S.(Istituto Gentili SpA)
参考来源:EP 0494844

Nebentan potassium, YM-598

奈苯坦Chemical Name: (E)-N-[6-Methoxy-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]-2-phenylethenesulfonamide potassium salt
CAS No. 403604-85-3 (free acid), 192645-26-4 (undefined isomer), 1...
参考文献标题:Arylethenesulfonamide derivs.and drug compsn.containing the same
文献作者:Harada,H.; Kazami,J.; Watanuki,S.; Tsuzuki,R.; Sudou,K.; Tanaka,A.(Yamanouchi Pharmaceutical Co.,Ltd.)
参考来源:EP 0882719; US 6083955; WO 9722595

Nemorubicin, PNU-152243, FCE-23762

奈莫柔比星 (7S,9S)-6,9,11-三羟基-9-(2-羟基乙酰基)-7-[5-羟基-4-[(2S)-2-甲氧基吗啉-4-基]-6-甲基四氢吡喃-2-基]氧基-4-甲氧基-8,10-二氢-7H-并四苯-5,12-二酮 Chemical Name: 3'-Deamino-3'-[2(S)-methoxymorpholin-4-yl]doxorubicin
CAS No. 108852-90...
参考文献标题:Novel morpholino derivs.of daunorubicins and doxorubicins
文献作者:Bargiotti,A.; Zini,P.; Penco,S.; Giuliani,F.(Pharmacia Corp.)
参考来源:BE 0904431; DE 3609052; GB 2172594; JP 1986221194; US 4672057

Neldazosin, HRO-2/145

奈达唑嗪Chemical Name: (?-1-(4-Amino-6,7-dimethoxyquinazolin-2-yl)-4-(3-hydroxybutyryl)piperazine; (?-1-(4-Amino-6,7-dimethoxyquinazolin-2-yl)-4-(3-hydroxy-1-oxobutyl)piperazine
CAS No. 109713-79-3
...
参考文献标题:Quinazoline derivs.,process for their preparation,pharmaceutical compsns.containing them and their use
文献作者:Schlager,L.H.(Gerot Pharmazeutika GmbH)
参考来源:EP 0225866; JP 1987132869; US 4795750

Nedaplatin, NSC-375101D, 254-S, Aqupla

奈达铂Chemical Name: cis-Diammine(glycolato-O1,O2)platinum
CAS No. 95734-82-0
项目整合开发状态: Launched-1995
项目研究机构: Shionogi (Originator)
合成路线:An aqueous solution of diamineplatinum nitrate (I) is ...
参考文献标题:Novel glycolic acid platinum complex and antineoplasticagent
文献作者:Shiratori,O.; Toya,T.; Aono,K.(Shionogi & Co.Ltd.)
参考来源:JP 1984222497

Nefiracetam, DM-9384, DZL-221, Translon

奈非西坦Chemical Name: N-(2,6-Dimethylphenyl)-2-(2-oxo-1-pyrrolidinyl)acetamide; 2-Oxo-1-pyrrolidinylacetic acid 2,6-dimethylanilide; 2-Oxo-1-pyrrolidineaceto-2',6'-xylidide
CAS No. 77191-36-7
项目整合开...
参考文献标题:Pyrrolidin-2-on-1-ylacetic acid 2,6-dimethylanilide,process of preparation and pharmaceutical compsns.containing them
文献作者:Betzing,H.; Biedermann,J.; Materne,C.; Neuser,V.(A.Nattermann & Cie.GmbH)
参考来源:DE 2924011