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Neridronate, Neridronic acid, AHHexBP, Nerixia

奈立膦酸Chemical Name: (6-Amino-1-hydroxyhexylidene)diphosphonic acid
CAS No. 79778-41-9
项目整合开发状态: Launched-2002
项目研究机构: Abiogen (Orphan Drug), Abiogen (Originator)
合成路线:The target product is obtained by phosphorylation of aminocaproic acid (I) by reflux with PCl3 / phosphorous acid (H3PO3) (directly or in chlorobenzene),followed by hydrolysis with boiling H2O.
📌 参考资料/链接:
参考文献标题:Process for the preparation of diphosphonic acids and salts thereof
文献作者:Guainai-Ricci,G.; Rosini,S.(Istituto Gentili SpA)
参考来源:EP 0494844

📄 详细内容


合成路线:The target product is obtained by phosphorylation of aminocaproic acid (I) by reflux with PCl3 / phosphorous acid (H3PO3) (directly or in chlorobenzene),followed by hydrolysis with boiling H2O.

参考文献标题:Process for the preparation of diphosphonic acids
文献作者:Staibano,G.(Istituto Gentili SpA)
参考来源:US 4705651


合成路线:The target product is obtained by phosphorylation of aminocaproic acid (I) by reflux with PCl3 / phosphorous acid (H3PO3) (directly or in chlorobenzene),followed by hydrolysis with boiling H2O.

参考文献标题:Process for the production of omega-amino-1-hydroxyalkylidene-1,1-bisphosphonic acid
文献作者:Blum,H.; Worms,K.-H.(Henkel KgA)
参考来源:US 4407761


合成路线:The target product is obtained by phosphorylation of aminocaproic acid (I) by reflux with PCl3 / phosphorous acid (H3PO3) (directly or in chlorobenzene),followed by hydrolysis with boiling H2O.
参考文献标题:
文献作者:
参考来源:US 4304734


产品链接: CAS No. 79778-41-9››