Nemorubicin, PNU-152243, FCE-23762
奈莫柔比星 (7S,9S)-6,9,11-三羟基-9-(2-羟基乙酰基)-7-[5-羟基-4-[(2S)-2-甲氧基吗啉-4-基]-6-甲基四氢吡喃-2-基]氧基-4-甲氧基-8,10-二氢-7H-并四苯-5,12-二酮 Chemical Name: 3'-Deamino-3'-[2(S)-methoxymorpholin-4-yl]doxorubicin
CAS No. 108852-90-0, 108943-08-4 (HCl)
项目整合开发状态: Phase II/III
项目研究机构: Pfizer (Originator)
合成路线:By condensation of 4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid ethyl ester (I) with N-methylaniline (II) by heating at 125 C and distillation of the ethanol formed.
合成路线:The oxidative cleavage of methyl beta-L-arabinopyranoside (I) with sodium periodate in water gives the dialdehyde (II),which is then cyclized with daunorubicin by means of NaHCO3 and sodium cyanoborohydride in acetonitrile/water.
📌 参考资料/链接：
参考文献标题:Novel morpholino derivs.of daunorubicins and doxorubicins
文献作者:Bargiotti,A.; Zini,P.; Penco,S.; Giuliani,F.(Pharmacia Corp.)
参考来源:BE 0904431; DE 3609052; GB 2172594; JP 1986221194; US 4672057
📄 详细内容
合成路线:The oxidative cleavage of methyl beta-L-arabinopyranoside (I) with sodium periodate in water gives the dialdehyde (II),which is then cyclized with daunorubicin by means of NaHCO3 and sodium cyanoborohydride in acetonitrile/water.
参考文献标题:Nemorubicin
文献作者:Graul,A.; Leeson,P.; Castar,J.
参考来源:Drugs Fut 1997,22(12),1239
产品链接: CAS No. 108852-90-0›› 产品链接: CAS No.108943-08-4››