项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
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项目整合精选

Cefuzonam sodium, CL-118523(free acid), LJC-10305, L-105, MTC.Na, CL-251931(free acid), Cosmosin

头孢唑喃Chemical Name: (6R,7R)-7beta-[2-(2-Aminothiazol-4-yl)-2(Z)-(methoxyimino)acetamido]-3-(1,2,3-thiadiazol-5-ylsulfanylmethyl)-3-cephem-4-carboxylic acid sodium salt
CAS No. 82219-78-1 (free acid)...
参考文献标题:Bisfentidine
文献作者:Scarpignato,C.
参考来源:Drugs Fut 1988,13(2),110

Cefotaxime sodium, HR-756, Claforan

头孢噻肟钠头孢噻肟 Chemical Name: (6R,7R)-3-(Acetoxymethyl)-7-[2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetamido]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid sodium salt
CAS No. 64485-93-4...
参考文献标题:Oxime derivatives of 7-aminothiazolylacetamidocephalosporanic acid processes for preparing them and pharmaceutical compositions incorporating them
文献作者:Heymes,R.; Lutz,A.(Aventis Pharma SA)
参考来源:BE 0850662; ES 455089; ES 466539; GB 1580621; GB 1580623; JP 52102293; JP 5247013

Cefodizime, THR-221, HR-221, Timecef, Modivid, Diezime

头孢地嗪酸Chemical Name: [6R-[6alpha,7beta(Z)[[-7-[[(2-Amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-[[[[5-(carboxymethyl)-4-methyl-2-thiazolyl]thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-ca...
参考文献标题:Cephem derivative
文献作者:Duerckeimer,W.; et al.(Aventis Pharma AG)
参考来源:BE 0865632; FR 2385722; GB 1604971; JP 5706887; US 4278793

Cefdinir, PD-134393, CI-983, FR-80482, FK-482, Omnicef, Cefzon

头孢地尼Chemical Name: (6R,7R)-7-[2-(2-Aminothiazol-4-yl)-2(Z)-(hydroxyimino)acetamido]-3-vinyl-3-cephem-4-carboxylic acid
CAS No. 91832-40-5
项目整合开发状态: Launched-1991
项目研究机构: Fujisawa (Originator)...
参考文献标题:Syn-isomer of 7-substd.-3-vinyl-3-cephem cpds.,pr
文献作者:Kawabata,K.; Masugi,T.; Takaya,T.; Taksugi,H.; Yamanaka,H.(Fujisawa Pharmaceutical Co.,Ltd.)
参考来源:EP 0105459; ES 8600309; ES 8800235; US 4559334

Cefditoren pivoxil, ME-1207, Spectracef, Meiact

头孢妥仑匹酯Chemical Name: (6R,7R)-7-[2-(2-Aminothiazol-4-yl)-2(Z)-(methoxyimino)acetamido]-3-[2(Z)-(4-methylthiazol-5-yl)vinyl]-3-cephem-4-carboxylic acid pivaloyloxymethyl ester; (6R,7R)-7-[2-(2-Amino-4-t...
参考文献标题:New cephalosporin cpds.and the production thereof
文献作者:Atsumi,K.; Sakagami,K.; Yamamoto,Y.; Yoshida,T.; Nishihata,K.; Kondo,S.; Fukatsu,S.(Meiji Seika Kaisha,Ltd.)
参考来源:EP 0175610; ES 8704955; JP 1986178991; JP 1987019593

Cefamandole, Mandokef, Kefadol, Kefandol, Mandol

头孢孟多Chemical Name: (6R,7R)-7-[2(R)-hydroxy-2-phenylacetamido]-3-(1-methyl-1H-tetraazol-5-ylsulfanylmethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
CAS No. 34444-01-4
项目整合开发状态...
参考文献标题:Cefamandole derivatives
文献作者:Tensmeyer,L.G.(Eli Lilly and Company)
参考来源:US 3947414

Cefonicid sodium, SK&F-D-75073-Z2, Monocid

头孢尼西钠头孢尼西 Chemical Name: [6R-[6alpha,7beta(R*)]]-7-[(Hydroxyphenylacetyl)amino]-8-oxo-3-[[[1-(sulfomethyl)-1H-tetrazol-5-yl]thio]methyl]-5-thia]-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid disodiu...
参考文献标题:Cefonicid sodium
文献作者:Castar,J.; Serradell,M.N.; Thorpe,P.; Blancafort,P.
参考来源:Drugs Fut 1979,4(9),634

Ceftibuten, Sch-39720, 7432-S, Ceprifran, Keimax, Isocef, Cedax, Ceftem

头孢布烯Chemical Name: (6R,7R)-7-[(Z)-2-(2-Aminothiazol-4-yl)-4-carboxy-2-butenoylamino]-3-cephem-4-carboxylic acid; (+)-(6R,7R)-7-[(Z)-2-(2-Amino-4-thiazolyl)-4-carboxycrotonamido]-8-oxo-5-thia-1-azabicy...
参考文献标题:7-Carboxyalkenoylamido-3-cephem-4-carboxylic acid derivs.
文献作者:Hamashima,Y.(Shionogi & Co.Ltd.)
参考来源:EP 0136721; ES 8604602; ES 8605278; ES 8700222; GB 2154580; GB 2198727; JP 1985078987; JP 1985163884; JP 1985246388; US 4634697; US 4748170

Ceftriaxone sodium, Ro-139904, Lendacin, Rocefalin, Rocephalin, Rocefin, Longaceph, Rocephine, Rocephin

头孢曲松钠头孢曲松 Chemical Name: (6R,7R)-7-[2-(2-Amino-4-thiazolyl)-2[(Z)-methoxyimino]acetamido]-3-[[(2,5-dihydro-6-hydroxy-2-methyl-5-oxo-as-triazin-3-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-...
参考文献标题:Cephalosporin derivs.and process for their preparation
文献作者:Reiner,R.; Montavon,M.(F.Hoffmann-La Roche AG)
参考来源:DE 2922036

Cefotetan disodium, ICI-156834(free acid), YM-09330, Cefotan, Apatef, Yamatetan

头孢替坦Chemical Name: 7beta-[4-(Carbamoylcarboxylatomethylene)-1,3-dithietan-2-yl]carboxamido-7alpha-methoxy-3-(1-methyltetrazol-5-yl)thiomethyl-3-cephem-4-carboxylic acid disodium salt; (6R,7S)-7-[4-(Ca...
参考文献标题:Cefotetan
文献作者:Blancafort,P.; Castar,J.; Sweetman,A.J.; Serradell,M.N.
参考来源:Drugs Fut 1981,6(10),609