项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
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项目整合精选

Cefetamet pivoxil, Ro-15-8075, Globocef, Cefyl

头孢他美酯Chemical Name: (6R,7R)-7-[2-(2-Aminothiazol-4-yl)-(Z)-2-(methoxyimino)acetamido]-3-methyl-3-cephem-4-carboxylic acid pivaloyloxymethyl ester; [6R-[6alpha,7beta(Z)]]-7-[2-(2-Aminothiazol-4-yl)-2-(...
参考文献标题:Cephalosporin derivatives for oral administration
文献作者:Nakao,H.; Sugawara,S.(Sankyo Co.,Ltd.)
参考来源:DE 3020625

Cefaclor, S-6472, Raniclor, Dystaclor MR, Ceclor, L-Kefral

头孢克罗头孢克洛 Chemical Name: (6R,7R)-7-[(R)-2-Amino-2-phenylacetamido]-3-chloro-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; (6R,7R)-7-[2(R)-Amino-2-phenylacetamido]-3-chloro-3-cephem-4-ca...
参考文献标题:Alpha-aminoacyl-3-halo-cephalosporins
文献作者:Chauvette,R.R.(Eli Lilly and Company)
参考来源:DE 2408698; ES 423531; FR 2218877; GB 1461323; JP 49110689; JP 56138190

Cefpirome, HR-810, Cefrom(sulfate), Broact(sulfate), Keiten(sulfate)

头孢匹罗硫酸头孢匹罗 Chemical Name: 1-[[(6R,7R)-7-[2-(2-Amino-4-thiazolyl)glyoxylamido]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-6,7-dihydro-5H-1-pyrindinium hydroxide,inner salt,7(2)-(Z...
参考文献标题:Cephalosporin derivatives
文献作者:Lattrell,R.; Wieduwilt,M.; Duerckheimer,W.; Blumbach,J.; Seeger,K.(Aventis SA)
参考来源:EP 0064740; FR 2511682; FR 2515654; GB 2098216; JP 57192394; US 5071979

Cefpiramide sodium, SM-1652, Tamicin, Suncefal, Sepatren

头孢匹胺Chemical Name: 7-[D-(-)-2-(4-Hydroxy-6-methylpyridin-3-ylcarboxamido)-2-(4-hydroxyphenyl)acetamido]-3-(1-methyl-1H-tetrazol-5-ylsulfanylmethyl)-3-cephem-4-carboxylic acid sodium salt
CAS No. 70...
参考文献标题:N-acylamino-alpha-arylacetamido cephalosporins and antibacterial compositions and methods containing them
文献作者:Yamada,H.; et al.(Sumitomo Chemical Co.,Ltd.)
参考来源:DE 2539664; ES 456652; FR 2283688; GB 1510730; US 4156724

BAL-9141, Ro-63-9141/000, Ro-63-9141

头孢吡普Chemical Name: (6R,7R)-7-[2-(5-Amino-1,2,4-thiadiazol-3-yl)-2(Z)-(hydroxyimino)acetamido]-3-[(E)-1-[3(R)-pyrrolidinyl]-2-oxopyrrolidin-3-ylidenemethyl]-3-cephem-4-carboxylic acid
CAS No. 209467...
参考文献标题:Vinyl pyrrolidine cephalosporins with basic substitutents
文献作者:Page,M.; Hebeisen,P.; Angehrn,P.; Heinze-Krauss,I.; Runtz,V.(F.Hoffmann-La Roche AG)
参考来源:EP 0849269; US 5981519

Cefepime, BMY-28142, Axepim, Maxipime

头孢吡肟Chemical Name: [6R-[6alpha,7beta(Z)]]-1-[7-[(2-Amino-4-thiazolyl)(methoxyimino)acetylamino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-ylmethyl]-1-methylpyrrolidinium hydroxide inner sal...
参考文献标题:Synthesis of 7-[alpha-(2-amino-[2-14C]thiazol-4-yl)-alpha-(Z)-methoxyiminoacetamido]-3-(1-methylpyrrolidinio)methyl-3-cephem-4-carboxylate hydrochloride ([14C]cefepime hydrochloride)
文献作者:Swigor,J.E.; Standridge,R.T.
参考来源:J Label Compd Radiopharm 1993,33(8),759

Cefuroxime, Zinacef

头孢呋肟Chemical Name: [6R-[6alpha,7beta(Z)]]-3-[(Aminocarbonyl)oxy]ethyl]-7-[2-furanyl(methoxyimino)acetamido]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
CAS No. 55268-75-2
项目整合开发状...
参考文献标题:7-Hydrocarbonoxyiminoacetamido-3-carbamoyloxy methylceph-3-em-4 carboxylic acids
文献作者:Cook,M.C.; et al.(Glaxo Group Ltd.)
参考来源:US 3974153

Cefuroxime axetil, SN-407, CCI-15641, Lifurox, Zinat, Elobact, Ceftin, Zinnat, Maxitil

头孢呋辛酯头孢呋肟头孢呋辛钠Chemical Name: [6R-[6alpha,7beta(Z)]]-3-[[(Aminocarbonyl)oxy]methyl]-7-[[2-furanyl(methoxyimino)acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 1-(acetyloxy)e...
参考文献标题:Cephalosporins antibiotics
文献作者:Gregson,M.; Sykes,R.B.(Glaxo Group Ltd.)
参考来源:DE 2706413; FR 2340950; JP 52100494; US 4267320

Cefpimizole sodium, U-63196E(free acid), AC-1370(free acid), Renilan, Ajicef

头孢咪唑钠头孢咪唑 Chemical Name: 7-beta-[D-(-)-alpha-(5-Carboxyimidazole-4-carboxamido)-alpha-phenylacetamido)-3-(4-beta-sulfoethyl-1-pyridinium)methyl-3-cephem-4-carboxylic acid monosodium salt
CAS No. 8...
参考文献标题:Imidazoledicarboxylic acid substituted cephalosporin derivatives
文献作者:Yasuda,N.; Eguchi,C.; Okutsu,M.; Hirose,Y.(Ajinomoto Co.,Inc.)
参考来源:DE 2826546; FR 2394550; JP 54005974; US 4217450

Cefoperazone sodium, T-1551, Cefoperazin, Cefoper, Cefobis

头孢哌酮钠头孢哌酮 Chemical Name: 7-[D-(-)-alpha-(4-Ethyl-2,3-dioxo-1-piperazinecarboxamido)-alpha-(4-hydroxyphenyl)acetamido]-3-[(1-methyl-1H-tetrazol-5-yl)thiomethyl]-3-cephem-4-carboxylic acid sodium salt<...
参考文献标题:Process for preparation of novel penicilins and cephalosporins
文献作者:Saikawa,I.; et al.(Toyama Chemical Co.,Ltd.)
参考来源:JP 52036684