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项目整合精选>>>Cefuroxime axetil, SN-407, CCI-15641, Lifurox, Zinat, Elobact, Ceftin, Zinnat, Maxitil
Cefuroxime axetil, SN-407, CCI-15641, Lifurox, Zinat, Elobact, Ceftin, Zinnat, Maxitil
头孢呋辛酯 头孢呋肟 头孢呋辛钠Chemical Name: [6R-[6alpha,7beta(Z)]]-3-[[(Aminocarbonyl)oxy]methyl]-7-[[2-furanyl(methoxyimino)acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 1-(acetyloxy)ethyl ester
CAS No. 64544-07-6, 55268-75-2 (free acid), 56238-63-2 (Na salt)
项目整合开发状态: Launched-1987
项目研究机构: GlaxoSmithKline (Originator)
合成路线:The reaction of 3-hydroxymethyl-7-[2-(2-furyl)-2-methoxyiminoacetamido]-3-cephem-4-carboxylic acid (I) with chlorosulfonyl isocyanate (II) and then with sodium 2-ethylhexanoate gives sodium cefuroxime (III),which is then treated with 1-bromoethyl acetate (IV) in DMA.
📌 参考资料/链接：
参考文献标题:Cephalosporins antibiotics
文献作者:Gregson,M.; Sykes,R.B.(Glaxo Group Ltd.)
参考来源:DE 2706413; FR 2340950; JP 52100494; US 4267320
📄 详细内容
合成路线:The reaction of 3-hydroxymethyl-7-[2-(2-furyl)-2-methoxyiminoacetamido]-3-cephem-4-carboxylic acid (I) with chlorosulfonyl isocyanate (II) and then with sodium 2-ethylhexanoate gives sodium cefuroxime (III),which is then treated with 1-bromoethyl acetate (IV) in DMA.
参考文献标题:Amorphous form of cefuroxime ester
文献作者:Crisp,H.A.; Clayton,J.C.(Glaxo Group Ltd.)
参考来源:DE 3327449; EP 0107276; FR 2531087; GB 2127401; JP 59044391; US 4562181; US 4820833; US 4994567; US 55013833
合成路线:The reaction of 3-hydroxymethyl-7-[2-(2-furyl)-2-methoxyiminoacetamido]-3-cephem-4-carboxylic acid (I) with chlorosulfonyl isocyanate (II) and then with sodium 2-ethylhexanoate gives sodium cefuroxime (III),which is then treated with 1-bromoethyl acetate (IV) in DMA.
参考文献标题:Cefuroxime Axetil
文献作者:Serradell,M.N.; Castar,J.
参考来源:Drugs Fut 1985,10(2),112