Cefpimizole sodium, U-63196E(free acid), AC-1370(free acid), Renilan, Ajicef
头孢咪唑钠 头孢咪唑 Chemical Name: 7-beta-[D-(-)-alpha-(5-Carboxyimidazole-4-carboxamido)-alpha-phenylacetamido)-3-(4-beta-sulfoethyl-1-pyridinium)methyl-3-cephem-4-carboxylic acid monosodium salt
CAS No. 85287-61-2, 84880-03-5 (free acid)
项目整合开发状态: Launched-1987
项目研究机构: Ajinomoto (Originator), Mochida (Originator)
合成路线:The reaction of imidazole-4,5-dicarboxylic acid (I) with SOCl2 in refluxing benzene gives the corresponding acid chloride (II),which is condensed with 7-beta-[D-(-)-alpha-aminophenylacetamido]cephalosporanic acid sodium salt (III) by means of triethylamine in dichloromethane to afford 7-beta-[D-(-)-alpha-[4(5)-carboxyimidazole-5(4)-carboxamido]phenyl acetamidolcephalosporanic acid (IV).Finally,this compound is condensed with 4-pyridineethanesulfonic acid (V) by means of NaI in water at 70 C.
📌 参考资料/链接：
参考文献标题:Imidazoledicarboxylic acid substituted cephalosporin derivatives
文献作者:Yasuda,N.; Eguchi,C.; Okutsu,M.; Hirose,Y.(Ajinomoto Co.,Inc.)
参考来源:DE 2826546; FR 2394550; JP 54005974; US 4217450
📄 详细内容
合成路线:The reaction of imidazole-4,5-dicarboxylic acid (I) with SOCl2 in refluxing benzene gives the corresponding acid chloride (II),which is condensed with 7-beta-[D-(-)-alpha-aminophenylacetamido]cephalosporanic acid sodium salt (III) by means of triethylamine in dichloromethane to afford 7-beta-[D-(-)-alpha-[4(5)-carboxyimidazole-5(4)-carboxamido]phenyl acetamidolcephalosporanic acid (IV).Finally,this compound is condensed with 4-pyridineethanesulfonic acid (V) by means of NaI in water at 70 C.
参考文献标题:AC-1370
文献作者:Castar,J.; Serradell,M.N.; Blancafort,P.
参考来源:Drugs Fut 1982,7(6),373
产品链接: CAS No. 85287-61-2›› 产品链接: CAS No.84880-03-5››