项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
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项目整合精选

Imiloxan, RS-21361

咪洛克生盐酸艾美洛沙Chemical Name: (?-2-[(2,3-Dihydro-1,4-benzodioxin-2-yl)methyl]-1-ethyl-1H-imidazole; (?-2-[(1,4-Benzodioxan-2-yl)methyl]-1-ethyl-1H-imidazole; (?-2-(1-Ethyl-2-imidazolyl)methyl-1,4-benzodiox...
参考文献标题:2-(1,4-Benzodioxan-2-ylalkyl)miidazoles useful as antidepressants
文献作者:Kluge,A.F.; Strosberg,A.M.; Whiting,R.; Christie,G.(Syntex (USA),Inc.)
参考来源:EP 0047531; JP 57050989; US 4302469

Miroprofen, Y-9213

咪洛芬Chemical Name: 2-[4-(Imidazo[1,2-a]pyridin-2-yl)phenyl]propionic acid; 4-Imidazo[1,2-a]pyridin-2-yl-alpha-methylbenzeneacetic acid
CAS No. 55843-86-2, 55843-87-3 (HCl)
项目整合开发状态: Biological Te...
参考文献标题:Y-9213
文献作者:Hillier,K.
参考来源:Drugs Fut 1979,4(5),373

Imirestat, AL01576, Hoe-843, AL-1576

咪瑞司他Chemical Name: 2,5-Difluorospiro(fluoren-9,4'-imidazolidine)-2',5'-dione
CAS No. 89391-50-4, 96351-85-8 (AL-1576)
项目整合开发状态: Phase III
项目研究机构: Alcon (Originator)
合成路线:The reaction of 2,...
参考文献标题:Spiro-tricycloaromatic succinimide derivs.as inhibitors of aldose reductase
文献作者:York,B.M.Jr.(Alcon Laboratories,Inc.)
参考来源:EP 0137333; ES 8800572; ES 8800915; ES 8900214; US 4537892

Mifentidine, DA-4577

咪芬替丁Chemical Name: N-[4-(1H-Imidazol-4-yl)phenyl]-N'-(1-methylethyl)methanimidamide; N-[4-(4-Imidazolyl)phenyl]-N'-isopropylformamidine; 4(5)-(4-Isopropylaminomethyleneiminophenyl)imidazole
CAS No....
参考文献标题:Mifentidine
文献作者:Serradell,M.N.; de Angelis,L.; Castar,J.
参考来源:Drugs Fut 1984,9(11),825

Imidafenacin, ONO-8025, KRP-197, Staybla

咪达那新Chemical Name: 4-(2-Methyl-1H-imidazolyl-1-yl)-2,2-diphenylbutyramide
CAS No. 170105-16-5
项目整合开发状态: Phase III
项目研究机构: Kyorin (Originator), Ono (Licensee)
合成路线:Alkylation of diphenylace...
参考文献标题:Novel imidazole deriv.and process for producing the same
文献作者:Miyachi,H.; Okazaki,K.; Kiyota,H.; Segawa,M.(Kyorin Pharmaceutical Co.,Ltd.)
参考来源:EP 0733621; US 5932607; US 6103747; WO 9515951

Rolipram, ME-3167, ZK-62711, Adeo

咯利普兰Chemical Name: 4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone
CAS No. 61413-54-5
项目整合开发状态: Phase III
项目研究机构: Schering AG (Originator)
合成路线:This compound can be obtained by thre...
参考文献标题:ROLIPRAM < Rec INN; USAN >
文献作者:Crossland,J.; Prous,J.; Castar,J.
参考来源:Drugs Fut 1988,13(1),38

Pipequaline, PK-8165

哌夸林Chemical Name: 2-Phenyl-4-(2-piperidin-4-ylethyl)quinoline; 2-Phenyl-4-[2-(4-piperidinyl)ethyl]quinoline
CAS No. 77472-98-1
项目整合开发状态: Biological Testing
项目研究机构: Pharmuka (Originator)
合成...
参考文献标题:2-(4-Piperidyl)-1-(4-4-quinolyl)-ethanone derivs.,intermediates in and process for their preparation,and their use as medicines
文献作者:Champseix,A.A.; Lefur,G.R.; Renault,C.L.A.(Pharmindustrie)
参考来源:EP 0031753

Piflutixol

哌氟替索Chemical Name: 2-[1-[3(Z)-[7-Fluoro-2-(trifluoromethyl)-10H-dibenzo[b,e]thiopyran-10-ylidene]propyl]piperidin-4-yl]ethanol
CAS No. 54341-02-5
项目整合开发状态: Not Determined
项目研究机构:
合成路线:The...
参考文献标题:
文献作者:Buus,J.M.L.; et al.
参考来源:DE 2631389

Perifosine, KRX-0401, NKA17, D-21266

哌立福新Chemical Name: N,N-Dimethylpiperidinium-4-yl(octadecyl)phosphate; 1,1-Dimethyl-4-[[(octadecyloxy)hydroxyphosphoryl]oxy]piperidinium inner salt
CAS No. 157716-52-4
项目整合开发状态: Phase II
项目研究机...
参考文献标题:Perifosine
文献作者:Engel,J.; Hilgard,P.; Nsner,G.; Voss,V.; Traiser,M.; Klenner,T.; Kutscher,B.
参考来源:Drugs Fut 2000,25(12),1257

Picenadol hydrochloride, LY-136595((-)-enantiomer), LY-136596((+)-enantiomer), LY-150720

哌西那朵Chemical Name: (?-trans-3-(1,3-Dimethyl-4-propyl-4-piperidinyl)phenol hydrochloride; (?-trans-m-(1,3-Dimethyl-4-propyl-4-piperidyl)phenol hydrochloride; (?-trans-1,3-Dimethyl-4-propyl-4-(3-hydroxy...
参考文献标题:1,3,4-Trisubstituted-4-arylpiperidines and their preparation
文献作者:Zimmerman,D.M.(Eli Lilly and Company)
参考来源:BE 0833044; DE 2539452; FR 2283679; FR 2299337; GB 1525584; JP 7648670; JP 7783572