项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
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项目整合精选

Indanidine hydrochloride(Rec INNM), Sgd-10175

吲达尼定Chemical Name: 4-(2-Imidazolin-2-ylamino)-2-methylindazole hydrochloride
CAS No. 85392-79-6 (free base)
项目整合开发状态: Preclinical
项目研究机构: Siegfried (Originator)
合成路线:4-Nitro-2-methylindazo...
参考文献标题:1H- and 2H-indazole derivs.and medicaments containing them
文献作者:Molnar,I.; Thiele,K.; Geissmann,F.; Jahn,U.(Siegfried AG)
参考来源:EP 0047328

Indalpine

吲达平Chemical Name: 3-[2-(4-Piperidinyl)ethyl]-1H-indole
CAS No. 63758-79-2
项目整合开发状态: Not Determined
项目研究机构:
合成路线:The reaction of N-carbobenzoxy-4-piperidylacetic acid (I) with refluxing SO...
参考文献标题:
文献作者:Champseix,A.; et al.
参考来源:US 4064255

Furnidipine, Furaldipine, CRE-319

呋尼地平Chemical Name: (RR,SS)-2,6-Dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-tetrahydrofurfuryl 5-methyl diester; (?-2,6-Dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dic...

Fuprazole

呋普拉唑Chemical Name: 1-(2-Furyl)-3-[2-[4-[3-phenyl-2(E)-propenyl]piperazin-1-ylmethyl]-1H-benzimidazol-1-yl]propan-1-one
CAS No. 60248-23-9
项目整合开发状态: Not Determined
项目研究机构:
合成路线:The reactio...
参考文献标题:
文献作者:Fauran,C.; et al.
参考来源:BE 835132; CA 1002042; CH 578561; DE 2552151; FR 2291755; GB 1487143; JP 7675081; JP 7941596; NL 7513599; US 4029879; ZA 7506925

Furofenac, SAS-650

呋罗芬酸Chemical Name: 2-(2-Ethyl-2,3-dihydro-1-benzofuran-5-yl)acetic acid
CAS No. 56983-13-2
项目整合开发状态: Not Determined
项目研究机构:
合成路线:It can be prepared in three different ways):1) By reductio...
参考文献标题:
文献作者:Tamagnone,G.F.; De Marchi,F.
参考来源:US 4029811

Carazolol, BM-51052

咔唑心安Chemical Name: 1-(9H-Carbazol-4-yloxy)-3-(isopropylamino)-2-propanol
CAS No. 57775-29-8
项目整合开发状态: Not Determined
项目研究机构:
合成路线:By condensation of 4-hydroxycarbazole (I) with epichloroh...
参考文献标题:Triyclic diphenylamines derivatives
文献作者:Leinert,H.; et al.(Boehringer Ingelheim GmbH)
参考来源:CH 598216; DE 2240599; FR 2196165; GB 1369580; JP 49056973

Mizolastine, MKC-431, SL-85.0324, Zolistam, Zolistan, Mizolen, Zolim, Mizollen

咪唑斯汀Chemical Name: 2-[N-[1-[1-(4-Fluorobenzyl)-1H-benzimidazol-2-yl]-4-piperidinyl]-N-methylamino]pyrimidin-4(3H)-one; 1-(4-Fluorobenzyl)-2-[4-[N-(3,4-dihydro-4-oxopyrimidin-2-yl)-N-methylamino]piperi...
参考文献标题:EP 217700,FR 2587029,JP 87061979,US 4820710
文献作者:Manoury,P.; Binet,J.; Defosse,G.(Sanofi-Synthabo )
参考来源:EP 0217700; FR 2587029; JP 1987061979; US 4820710

Midazogrel, CBS-645

咪唑格雷Chemical Name: (E)-1-[3-(Phenylmethoxy)-1-octenyl]-1H-imidazole; (E)-1-(3-Benzyloxyocten-1-yl)imidazole
CAS No. 80614-27-3
项目整合开发状态: Biological Testing
项目研究机构: Chauvin (Originator)
合成路...
参考文献标题:Therapeutic compsn.based on imidazoles,especially for the treatment of thromboses; imidazoles and process for their preparation
文献作者:Bonne,C.; Coquelet,C.; Sincholle,D.(Chauvin Laboratories SA)
参考来源:EP 0033432

Imiquimod, MTD-39, DZ-2636, R-837, S-26308, Zartra, Aldara

咪喹莫特Chemical Name: 1-Isobutyl-1H-imidazo[4,5-c]quinolin-4-amine; 1-(2-Methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amine
CAS No. 99011-02-6, 99011-78-6 (mono HCl salt)
项目整合开发状态: Launched-1997
项目...
参考文献标题:1H-Imidazo[4,5-c]quinolines and 1H-imidazo[4,5-c]quinolin-4-amines
文献作者:Gerster,J.F.(3M Pharmaceuticals)
参考来源:EP 0145340; US 4689338; US 4698348

Midaglizole hydrochloride, DG-5128

咪格列唑Chemical Name: 2-[2-Phenyl-2-(2-pyridyl)ethyl]imidazoline dihydrochloride sesquihydrate; 2-[2-(4,5-Dihydro-1H-imidazol-2-yl)-1-phenylethyl]pyridine dihydrochloride sesquihydrate
CAS No. 72157-0...
参考文献标题:DG-5128
文献作者:Castar,J.; Hillier,K.; Blancafort,P.; Serradell,M.N.
参考来源:Drugs Fut 1982,7(8),550