Indanidine hydrochloride(Rec INNM), Sgd-10175
吲达尼定Chemical Name: 4-(2-Imidazolin-2-ylamino)-2-methylindazole hydrochloride
CAS No. 85392-79-6 (free base)
项目整合开发状态: Preclinical
项目研究机构: Siegfried (Originator)
合成路线:4-Nitro-2-methylindazole (I) is reduced with H2 over Pd/C in ethyl acetate to give 4-amino-2-methylindazole (II).The condensation of a mixture of 4-amino-2-methylindazole (III) dissolved in tetrahydrofuran and 2-chloroimidazoline (A) in tetrahydrofuran solution in room temperature gives Sgd-101-75.
📌 参考资料/链接：
参考文献标题:1H- and 2H-indazole derivs.and medicaments containing them
文献作者:Molnar,I.; Thiele,K.; Geissmann,F.; Jahn,U.(Siegfried AG)
参考来源:EP 0047328
📄 详细内容
合成路线:4-Nitro-2-methylindazole (I) is reduced with H2 over Pd/C in ethyl acetate to give 4-amino-2-methylindazole (II).The condensation of a mixture of 4-amino-2-methylindazole (III) dissolved in tetrahydrofuran and 2-chloroimidazoline (A) in tetrahydrofuran solution in room temperature gives Sgd-101-75.
参考文献标题:SGD-101-75
文献作者:Ismail,S.; Coates,J.; Weetman,D.F.; Chadwick,M.A.; Turner,N.; Lawson,K.; Jahn,U.; Thiele,K.
参考来源:Drugs Fut 1983,8(7),603
产品链接: CAS No. 85392-79-6››