Indalpine
吲达平Chemical Name: 3-[2-(4-Piperidinyl)ethyl]-1H-indole
CAS No. 63758-79-2
项目整合开发状态: Not Determined
项目研究机构:
合成路线:The reaction of N-carbobenzoxy-4-piperidylacetic acid (I) with refluxing SOCl2 yields the corresponding acyl chloride (II),which by condensation with indole (III) by means of methylmagnesium iodide (A) in ether gives rise to 3-indolyl-(4-piperidylmethyl)ketone (IV).Finally,this compound is reduced with LiAlH4 in THF.
📌 参考资料/链接：
参考文献标题:
文献作者:Champseix,A.; et al.
参考来源:US 4064255
📄 详细内容
合成路线:The reaction of N-carbobenzoxy-4-piperidylacetic acid (I) with refluxing SOCl2 yields the corresponding acyl chloride (II),which by condensation with indole (III) by means of methylmagnesium iodide (A) in ether gives rise to 3-indolyl-(4-piperidylmethyl)ketone (IV).Finally,this compound is reduced with LiAlH4 in THF.
参考文献标题:Indalpine
文献作者:Blancafort,P.; Owen,R.T.; Castar,J.; Serradell,M.N.
参考来源:Drugs Fut 1979,4(12),873
产品链接: CAS No. 63758-79-2››