Midazogrel, CBS-645
咪唑格雷Chemical Name: (E)-1-[3-(Phenylmethoxy)-1-octenyl]-1H-imidazole; (E)-1-(3-Benzyloxyocten-1-yl)imidazole
CAS No. 80614-27-3
项目整合开发状态: Biological Testing
项目研究机构: Chauvin (Originator)
合成路线:The Oxidation of 1-octyn-3-ol (I) with chromium trioxide gives the 3-oxooctyne (II),which by reaction with imidazole (III) yields (E)-1-(3-oxoocten-1-yl)imidazole (IV).Reduction of this compound with sodium borohydride gives (E)-1,3-hydroxyocten-1-yl)imidazole (V) .Finally,the latter is etherified with benzyl chloride (VI).
📌 参考资料/链接：
参考文献标题:Therapeutic compsn.based on imidazoles,especially for the treatment of thromboses; imidazoles and process for their preparation
文献作者:Bonne,C.; Coquelet,C.; Sincholle,D.(Chauvin Laboratories SA)
参考来源:EP 0033432
📄 详细内容
合成路线:The Oxidation of 1-octyn-3-ol (I) with chromium trioxide gives the 3-oxooctyne (II),which by reaction with imidazole (III) yields (E)-1-(3-oxoocten-1-yl)imidazole (IV).Reduction of this compound with sodium borohydride gives (E)-1,3-hydroxyocten-1-yl)imidazole (V) .Finally,the latter is etherified with benzyl chloride (VI).
参考文献标题:CBS-645
文献作者:Blancafort,P.; Serradell,M.N.; Castar,J.
参考来源:Drugs Fut 1983,8(10),843
合成路线:The Oxidation of 1-octyn-3-ol (I) with chromium trioxide gives the 3-oxooctyne (II),which by reaction with imidazole (III) yields (E)-1-(3-oxoocten-1-yl)imidazole (IV).Reduction of this compound with sodium borohydride gives (E)-1,3-hydroxyocten-1-yl)imidazole (V) .Finally,the latter is etherified with benzyl chloride (VI).
参考文献标题:
文献作者:Pailer,N.; Gutwiller,H.
参考来源:Mh Chem 1977,108(Suppl.1),653
产品链接: CAS No. 80614-27-3››