Miroprofen, Y-9213
咪洛芬Chemical Name: 2-[4-(Imidazo[1,2-a]pyridin-2-yl)phenyl]propionic acid; 4-Imidazo[1,2-a]pyridin-2-yl-alpha-methylbenzeneacetic acid
CAS No. 55843-86-2, 55843-87-3 (HCl)
项目整合开发状态: Biological Testing
项目研究机构: Meiji Seika (Originator), Mitsubishi Pharma (Originator)
合成路线:Compound can be prepared in two different ways:1) The cyclization of ethyl 2-[4-(chloroacetyl)phenyl]propionate (I) with 2-aminopyridine (II) in refluxing ethanol gives ethyl 2-[4-(imidazo[1,2-a]pyridin-2-yl)phenyl]propionate (III),which is then hydrolyzed with NaOH in refluxing ethanol water.2) By cyclization of a mixture of pyridine (IV),hydroxylamine (V) and 2-[4-(chloroacetyl)phenyl]propionic acid (VI) by heating at 80-100 C.
📌 参考资料/链接：
参考文献标题:Y-9213
文献作者:Hillier,K.
参考来源:Drugs Fut 1979,4(5),373
📄 详细内容
合成路线:Compound can be prepared in two different ways:1) The cyclization of ethyl 2-[4-(chloroacetyl)phenyl]propionate (I) with 2-aminopyridine (II) in refluxing ethanol gives ethyl 2-[4-(imidazo[1,2-a]pyridin-2-yl)phenyl]propionate (III),which is then hydrolyzed with NaOH in refluxing ethanol water.2) By cyclization of a mixture of pyridine (IV),hydroxylamine (V) and 2-[4-(chloroacetyl)phenyl]propionic acid (VI) by heating at 80-100 C.
参考文献标题:
文献作者:Nakanishi,M.; et al.
参考来源:US 3978071
合成路线:Compound can be prepared in two different ways:1) The cyclization of ethyl 2-[4-(chloroacetyl)phenyl]propionate (I) with 2-aminopyridine (II) in refluxing ethanol gives ethyl 2-[4-(imidazo[1,2-a]pyridin-2-yl)phenyl]propionate (III),which is then hydrolyzed with NaOH in refluxing ethanol water.2) By cyclization of a mixture of pyridine (IV),hydroxylamine (V) and 2-[4-(chloroacetyl)phenyl]propionic acid (VI) by heating at 80-100 C.
参考文献标题:
文献作者:Muro,T.; Ogawa,K.
参考来源:JP 7703954
产品链接: CAS No. 55843-86-2››