Pipequaline, PK-8165
哌夸林Chemical Name: 2-Phenyl-4-(2-piperidin-4-ylethyl)quinoline; 2-Phenyl-4-[2-(4-piperidinyl)ethyl]quinoline
CAS No. 77472-98-1
项目整合开发状态: Biological Testing
项目研究机构: Pharmuka (Originator)
合成路线:The reaction of ethyl 2-phenylquinoline-4-carboxylate (I) with ethyl N-benzoylpiperidyl-4-acetate (II) by means of potassium tert-butylate in THF gives 2-phenyl-4-(4-piperidylacetyl)quinone (III),which is then reduced with hydrazine at 180 C.
📌 参考资料/链接：
参考文献标题:2-(4-Piperidyl)-1-(4-4-quinolyl)-ethanone derivs.,intermediates in and process for their preparation,and their use as medicines
文献作者:Champseix,A.A.; Lefur,G.R.; Renault,C.L.A.(Pharmindustrie)
参考来源:EP 0031753
📄 详细内容
合成路线:The reaction of ethyl 2-phenylquinoline-4-carboxylate (I) with ethyl N-benzoylpiperidyl-4-acetate (II) by means of potassium tert-butylate in THF gives 2-phenyl-4-(4-piperidylacetyl)quinone (III),which is then reduced with hydrazine at 180 C.
合成路线:The reaction of ethyl 2-phenylquinoline-4-carboxylate (I) with N-benzoylpipepidine-3-acetic acid ethyl ester (II) by means of potassium hydride in THF gives 2-phenyl-4-[2-(3-piperidyl)acetyl]quinoline (III),which is reduced with hydrazine in dietyleneglycol at 180 C.
参考文献标题:PK-8165 and PK-9084
文献作者:Blancafort,P.; McGillion,F.B.; Castar,J.; Serradell,M.N.
参考来源:Drugs Fut 1982,7(9),648
产品链接: CAS No. 77472-98-1››