Mifentidine, DA-4577
咪芬替丁Chemical Name: N-[4-(1H-Imidazol-4-yl)phenyl]-N'-(1-methylethyl)methanimidamide; N-[4-(4-Imidazolyl)phenyl]-N'-isopropylformamidine; 4(5)-(4-Isopropylaminomethyleneiminophenyl)imidazole
CAS No. 83184-43-4, 83184-44-5 (fumarate)
项目整合开发状态: Phase II
项目研究机构: De Angeli (Originator)
合成路线:This compound can be obtained through two different ways from 4-(4-aminophenyl)-1H-imidazole (I):1) By condensation of compound (I) with ethyl N-isopropylformimidate (II) in ethanol.2) The reaction of compound (I) with ethyl N-cyanoformimidate (III) gives N'-cyano-N-(4-1H-imidazol-4-ylphenyl)formamidine (IV),which is treated with isopropylamine (V).
📌 参考资料/链接：
参考文献标题:Mifentidine
文献作者:Serradell,M.N.; de Angelis,L.; Castar,J.
参考来源:Drugs Fut 1984,9(11),825
📄 详细内容
合成路线:This compound can be obtained through two different ways from 4-(4-aminophenyl)-1H-imidazole (I):1) By condensation of compound (I) with ethyl N-isopropylformimidate (II) in ethanol.2) The reaction of compound (I) with ethyl N-cyanoformimidate (III) gives N'-cyano-N-(4-1H-imidazol-4-ylphenyl)formamidine (IV),which is treated with isopropylamine (V).
参考文献标题:(Imidazoylphenyl)formamidines.A structurally novel class of potent histamine H2-receptor antagonists
文献作者:Donetti,A.; Cereda,E.; Bellora,E.; Gallazzi,A.; Bazzano,C.; Vanoni,P.; Del Soldato,P.; Micheletti,R.; Pagani,F.; Giachetti,A.
参考来源:J Med Chem 1984,27(3),380-386
合成路线:This compound can be obtained through two different ways from 4-(4-aminophenyl)-1H-imidazole (I):1) By condensation of compound (I) with ethyl N-isopropylformimidate (II) in ethanol.2) The reaction of compound (I) with ethyl N-cyanoformimidate (III) gives N'-cyano-N-(4-1H-imidazol-4-ylphenyl)formamidine (IV),which is treated with isopropylamine (V).
参考文献标题:Imidazolylphenyl amidines,pharmaceutical compositions containing same and use thereof
文献作者:Cereda,E.; Donetti,A.; Del Soldato,P.; Bergamoschi,M.
参考来源:EP 0053407; ES 8207147; ES 8207148; ES 8207149; ES 8207150; ES 8207151; ES 8207152; GB 2088375; JP 57120575; US 4386099; US 4465841
产品链接: CAS No. 83184-43-4››