其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Trilostane CAS Registry Number: 13647-35-3 曲洛司坦

CAS Name: (4a,5a,17b)-4,5-Epoxy-3,17-dihydroxyandrost-2-ene-2-carbonitrile
Additional Names: 4,5-epoxy-17-hydroxy-3-oxoandrostane-2-carbonitrile; 2a-cyano-4a,5a-epoxyandrostan-17b-ol-3-oneTrade...
Literature References: Prepn: R. O. Clinton, A. J. Manson, US 3296255 (1967 to Sterling); H. C. Neumann et al., J. Med. Chem. 13, 948 (1970). Inhibition of steroid biosynthesis: G. O. Potts et al., Steroids 32, 257 (1978). Disposition in animals: J. F. Baker et al., Arch. Int. Pharmacodyn. Ther. 243, 4 (1980). Metabolism in rats: Y. Mori et al., Chem. Pharm. Bull. 29, 2646 (1981); in humans: D. T. Robinson et al., J. Steroid Biochem. 21, 601 (1984). HPLC determn in plasma: P. Powles et al., J. Chromatogr. 311, 434 (1984); and of major metabolite, 17-ketotrilostane: R. R. Brown et al., ibid. 339, 440 (1985). Clinical study in Cushing's syndrome: P. Komanicky et al., J. Clin. Endocrinol. Metab. 47, 1042 (1978). Clinical trials in breast cancer: C. G. Beardwell et al., Cancer Chemother. Pharmacol. 10, 158 (1983); C. J. Williams et al., Cancer Treat. Rep. 71, 1197 (1987).

Oxandrolone CAS Registry Number: 53-39-4 氧甲氢龙

CAS Name: (4aS,4bS,6aS,7S,9aS,9bR,11aS)-Tetradecahydro-7-hydroxy-4a,6a,7-trimethylcyclopenta[5,6]naphtho[1,2-c]pyran-2(1H)-one
Additional Names: 17b-hydroxy-17a-methyl-2-oxa-5a-androstan-3-one;...
Literature References: Prepn: R. Pappo, C. J. Jung, Tetrahedron Lett. 9, 365 (1962); R. Pappo, US 3128283 (1964 to Searle).

Florantyrone CAS Registry Number: 519-95-9 夫洛梯隆

CAS Name: g-Oxo-8-fluoranthenebutanoic acid
Additional Names: b-(8-fluoranthoyl)propionic acid
Trademarks: Zanchol (Searle)
Percent Composition: C 79.46%, H 4.67%, O 15.88%
Literature References: Prepn: R. R. Burtner, US 2773091 (1956 to Searle). See also: O. E. Fancher, US 2560425 (1951 to Miles Labs).

Nifuroquine CAS Registry Number: 57474-29-0 硝呋罗喹

CAS Name: 4-(5-Nitro-2-furanyl)-2-quinolinecarboxylic acid 1-oxide
Additional Names: 2-carboxy-4-[2'-(5'-nitrofuryl)]quinoline 1-oxide; 4-(5-nitro-2-furyl)quinaldic acid 1-oxide; quinaldofur Literature References: Prepn: R. R. G. Haber, E. Schoenberger, ZA 6703320 corresp to US 4217456 and US 4224448 (1967, 1980, 1980). Use in bovine mastitis: R. R. G. Haber et al., DE 2612250 corresp to US 4070469 (1977, 1978 both to ABIC). In vitro study: G. Ziv et al., Zentralbl. Veterinaermed. (B) 23, 301 (1976). Pharmacology: G. Ziv, A. Saran, ibid. 310. Activity under anaerobic conditions: G. M. Maluszynska, L. Bassalik-Chabielska, Pr. Mater. Zootech. 23, 63 (1980), C.A. 93, 143793 (1980).

Picotamide CAS Registry Number: 32828-81-2 4-甲氧基-N,N'-二(3-吡啶甲基)-1,3-苯二甲酰胺

CAS Name: 4-Methoxy-N,N'-bis(3-pyridinylmethyl)-1,3-benzenedicarboxamide
Additional Names: 4-methoxy-N,N'-bis(3-pyridylmethyl)isophthalamide; N,N'-bis(3-picolyl)-4-methoxyisophthalamidePercent ...
Literature References: Prepn: R. Selleri et al., Chim. Ther. 6, 203 (1971); G. Orzalesi, R. Selleri, FR 2100850 C.A. 77, 164502f (1972); prepn and use as inhibitor of blood platelet aggregation: eidem, US 3973026 (1972, 1976 both to Soc. Italo-Brit. L. Manetti-H. Roberts). Crystal structure of monohydrate: E. Foresti et al., Acta Crystallogr. C42, 220 (1986). Mechanism of action study: M. Berrettini et al., Boll. Soc. Ital. Biol. Sper. 59, 309 (1983). Clinical studies: R. Schmutzler et al., Age Ageing 7, 246 (1978); V. Coto et al., Minerva Cardioangiol. 34, 601 (1986).

Thionaphthene-2-carboxylic Acid CAS Registry Number: 6314-28-9 苯并噻吩-2-羧酸

CAS Name: Benzo[b]thiophene-2-carboxylic acid
Additional Names: 2-benzothiophenecarboxylic acid; TNCAPercent Composition: C 60.66%, H 3.39%, O 17.96%, S 17.99%
Literature References: Prepn: R. Weissgerber, O. Kruber, Ber. 53, 1551 (1920); eidem, DE 341837 (1921), Frdl. 13, 279 (1921); D. A. Shirley, M. D. Cameron, J. Am. Chem. Soc. 72, 2788 (1950); T. Higa, A. J. Krubsack, J. Org. Chem. 41, 3399 (1976). Use as anti-osteoporotic agent: C. M. Samour, J. A. Vida, US 4101668 (1978 to Bristol-Myers). Effect on total skeletal calcium in mice: J. C. Robin et al., J. Med. 11, 15 (1980). Mechanism of action study: J. C. Robin et al., Calcif. Tissue Int. 36, 194 (1984). Hypocalcemic effect: A. J. Johannesson et al., Endocrinology 117, 1508 (1985).

Niaprazine CAS Registry Number: 27367-90-4 尼普拉嗪

CAS Name: N-[3-[4-(4-Fluorophenyl)-1-piperazinyl]-1-methylpropyl]-3-pyridinecarboxamide
Additional Names: N-[3-[4-(p-fluorophenyl)-1-piperazinyl]-1-methylpropyl]nicotinamide
Trademarks: Nopr...
Literature References: Prepn: R. Y. Mauvernay, DE 1957371 corresp to US 3712893 (1970, 1973 both to CERM). Pharmacology: P. Duchene-Marrullaz et al., Therapie 26, 1203 (1971). Psycholeptic effects in mice: J. Hache, J. Tachon, J. Pharmacol. 7, 469 (1976). Brain catecholamine depletion: P. E. Keane, M. S. Benedetti, Neuropharmacology 18, 595 (1979).

Oxaflumazine CAS Registry Number: 16498-21-8 奥沙氟嗪

CAS Name: 10-[3-[4-[2-(1,3-Dioxan-2-yl)ethyl]-1-piperazinyl]propyl]-2-(trifluoromethyl)-10H-phenothiazine
Percent Composition: C 61.52%, H 6.35%, F 11.23%, N 8.28%, O 6.30%, S 6.32%
Literature References: Prepn: Ratouis, Boissier, Bull. Soc. Chim. Fr. 1966, 2963; eidem, DE 1911719 (1969 to S.I.F.A.), C.A. 72, 55480y (1970). Pharmacology: Boissier, Dumont, Therapie 26, 481 (1971). Metabolism: Boissier et al., Ann. Pharm. Fr. 30, 851 (1972). Clinical studies: Deniker et al., Therapie 26, 227 (1971).

Meprylcaine CAS Registry Number: 495-70-5 美普卡因

CAS Name: 2-Methyl-2-(propylamino)-1-propanol benzoate (ester)
Additional Names: b-(n-propylamino)-b,b-dimethylethyl benzoate; 2-methyl-2-propylaminopropyl benzoate
Trademarks: Oracaine
P...
Literature References: Prepn: Reasenberg, US 2767207 (1956 to Mizzy).

Phenobutiodil CAS Registry Number: 554-24-5 碘芬布酸

CAS Name: 2-(2,4,6-Triiodophenoxy)butanoic acid
Additional Names: 2-(2,4,6-triiodophenoxy)butyric acid; a-(2,4,6-triiodophenoxy)butyric acid; 1-(2,4,6-triiodophenoxy)propanecarboxylic acidTrade...
Literature References: Prepn: Redel et al., Bull. Soc. Chim. Fr. 1954, 342; Redel, Maillard, US 2796432 (1957 to Chimie et Atomistique). Pharmacology: H. Bekker et al., Pharmazie 27, 411 (1972).