项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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Dichlobenil CAS Registry Number: 1194-65-6 2,6-二氯苯腈

CAS Name: 2,6-DichlorobenzonitrileTrademarks: Casoron (Solvay Duphar)
Percent Composition: C 48.88%, H 1.76%, Cl 41.22%, N 8.14%
Literature References: Prepn: Reich, Bull. Soc. Chim. Fr. [4] 21, 217 (1917); Norris, Klemka, J. Am. Chem. Soc. 62, 1432 (1940); Chang et al., C.A. 53, 6134d (1959); Koopman, Rec. Trav. Chim. 80, 1075 (1961); Hackmann, ten Haken GB 861899; Higson, GB 862937 (both 1961 to Shell). Use as herbicide: Koopman, Daams, US 3027248 (1962 to N. A. Phillips). Fate in crops, soil and animals: Beynon, Wright, Residue Rev. 43, 23 (1972); Veroop, ibid. 55. Toxicity data: G. W. Bailey, J. L. White, ibid. 10, 97 (1965).

Dichlobenil CAS Registry Number: 1194-65-6 2,6-二氯苯腈

CAS Name: 2,6-DichlorobenzonitrileTrademarks: Casoron (Solvay Duphar)
Percent Composition: C 48.88%, H 1.76%, Cl 41.22%, N 8.14%
Literature References: Prepn: Reich, Bull. Soc. Chim. Fr. [4] 21, 217 (1917); Norris, Klemka, J. Am. Chem. Soc. 62, 1432 (1940); Chang et al., C.A. 53, 6134d (1959); Koopman, Rec. Trav. Chim. 80, 1075 (1961); Hackmann, ten Haken GB 861899; Higson, GB 862937 (both 1961 to Shell). Use as herbicide: Koopman, Daams, US 3027248 (1962 to N. A. Phillips). Fate in crops, soil and animals: Beynon, Wright, Residue Rev. 43, 23 (1972); Veroop, ibid. 55. Toxicity data: G. W. Bailey, J. L. White, ibid. 10, 97 (1965).

Adrenosterone CAS Registry Number: 382-45-6 肾上腺甾酮

CAS Name: Androst-4-ene-3,11,17-trione
Additional Names: Reichstein's substance G
Percent Composition: C 75.97%, H 8.05%, O 15.98%
Literature References: Prepn: Reichstein, Helv. Chim. Acta 19, 29, 1107 (1936); Kendall et al., J. Biol. Chem. 116, 267 (1936); Reichstein, Helv. Chim. Acta 20, 817, 953 (1937). Total synthesis: Velluz et al., Compt. Rend. 250, 1293 (1960). Crystal structure: Ohrt et al., Acta Crystallogr. 19, 479 (1965). Metabolism: Bradlow et al., Steroids 10, 233 (1967).

Butyl Carbitol® (Union Carbide) CAS Registry Number: 112-34-5 二乙二醇丁醚

CAS Name: 2-(2-Butoxyethoxy)ethanol
Additional Names: diethylene glycol monobutyl ether; butyl digol
Trademarks: Butyl Diicinol (ICI)
Percent Composition: C 59.23%, H 11.18%, O 29.59%
Literature References: Prepn: Riemschneider, Gross, Monatsh. Chem. 90, 783 (1959). Purification: Miller, Yonan, J. Am. Chem. Soc. 79, 5931 (1957); Ridley, Ridley, GB 795866 (1958 to Esso). Toxicity data: Smyth et al., J. Ind. Hyg. Toxicol. 23, 259 (1941).

Dipyrocetyl CAS Registry Number: 486-79-3 地匹乙酯

CAS Name: 2,3-Bis(acetyloxy)benzoic acid
Additional Names: o-pyrocatechuic acid diacetate; diacetylpyrocatechol-3-carboxylic acid; 2,3-diacetoxybenzoic acid
Trademarks: Movirene; Artromialgi...
Literature References: Prepn: Rietz, US 1140716 (1914); Simokoriyama, Bull. Chem. Soc. Jpn. 16, 284 (1941).

p-Methyldiphenhydramine CAS Registry Number: 19804-27-4 托拉代尔

CAS Name: N,N-Dimethyl-2-[(4-methylphenyl)phenylmethoxy]ethanamine
Additional Names: N,N-dimethyl-2-[(p-methyl-a-phenylbenzyl)oxy]ethylamine; b-dimethylaminoethyl 4-methylbenzhydryl ether; p-me...
Literature References: Prepn: Rieveschl, US 2527962 (1950 to Parke, Davis); GB 683483 (1952 to Fabriken Brocades-Stheeman Pharmacia).

Bromodiphenhydramine CAS Registry Number: 118-23-0 溴苯海明

CAS Name: 2-[(4-Bromophenyl)phenylmethoxy]-N,N-dimethylethanamine
Additional Names: 2-(p-bromo-a-phenylbenzyloxy)-N,N-dimethylethylamine; b-(p-bromobenzhydryloxy)ethyldimethylamine; b-dimethyla...
Literature References: Prepn: Rieveschl, US 2527963 (1950 to Parke, Davis).

Ferrous Hydroxide CAS Registry Number: 18624-44-7

Percent Composition: Fe 62.15%, H 2.24%, O 35.61%
Literature References: Prepn: Rihl, Fricke, Z. Anorg. Allg. Chem. 251, 406 (1943); Leussing, Kolthoff, J. Am. Chem. Soc. 75, 2476 (1953). Oxidation products: Feitknecht, Keller, Z. Anorg. Chem. 262, 61 (1950); Mayne, J. Chem. Soc. 1953, 129; Shipko, Douglas, J. Phys. Chem. 60, 1519 (1956).

Delmadinone Acetate CAS Registry Number: 13698-49-2 醋酸地马孕酮

CAS Name: 17-(Acetyloxy)-6-chloropregna-1,4,6-triene-3,20-dione
Additional Names: 6-chloro-17-hydroxypregna-1,4,6-triene-3,20-dione acetate; 1,6-bisdehydro-6-chloro-17a-acetoxyprogesterone; D1-...
Literature References: Prepn: Ringold et al., J. Am. Chem. Soc. 81, 3485 (1959); GB 890315 (1962 to Upjohn), C.A. 57, 5996c (1962); 76, 14813y (1972); Campbell, Babcock, DE 1243682 (1967 to Upjohn), C.A. 67, 100343r (1967). Activity studies: Dorfman, Kincl, Steroids 1, 185 (1963); Weichert et al., Arzneim.-Forsch. 17, 1103 (1967); Gerber et al., J. Small Anim. Pract. 14, 151 (1973).

Ambuside CAS Registry Number: 3754-19-6 安布赛特

CAS Name: 4-Chloro-6-[(3-hydroxy-2-butenylidene)amino]-N1-2-propenyl-1,3-benzenedisulfonamide
Additional Names: N'-allyl-4-chloro-6-[(3-hydroxy-2-butenylidene)amino]-m-benzenedisulfonamide; 2-(...
Literature References: Prepn: Robertson, FR 1331680 (1963 to Lakeside), corresp to US 3188329 (1965 to Colgate-Palmolive); Robertson et al., J. Med. Chem. 8, 90 (1965).