其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Todralazine CAS Registry Number: 14679-73-3 乙肼莱哒嗪

CAS Name: 2-(1-Phthalazinyl)hydrazinecarboxylic acid ethyl ester
Additional Names: 3-(1-phthalazinyl)carbazic acid ethyl ester; N1-carbethoxy-N2-phthalazinehydrazine; carboethoxyphthalazinohydr...
Literature References: Prepn: S. Biniecki et al., Bull. Acad. Pol. Sci. Ser. Sci. 6, 227 (1958), C.A. 52, 18424g (1958); eidem, BE 647722; eidem, US 3591588 (1964, 1971 both to Polfa). Spectrofluorometric determn in plasma: A. Ishii, T. Deguchi, Chem. Pharm. Bull. 26, 2241 (1978). Pharmacological study: M. Filczewski, E. Boguka, Pol. J. Pharmacol. Pharm. 31, 127 (1979), C.A. 91, 204508 (1979). Absorption, distribution, excretion in rats and humans: A. Ishii et al., Oyo Yakuri 18, 61 (1979), C.A. 92, 104012 (1980). Clinical study: W. Reiterer, H. Czitober, Arzneim.-Forsch. 27, 2163 (1977). Toxicity study: F. Parravincini et al., Farmaco Ed. Sci. 34, 299 (1979).

Trimethyl Orthovalerate CAS Registry Number: 13820-09-2 原戊酸三甲酯

CAS Name: 1,1,1-Trimethoxypentane
Additional Names: methyl orthovalerate
Percent Composition: C 59.23%, H 11.18%, O 29.59%
Literature References: Prepn: S. M. McElvain et al., J. Am. Chem. Soc. 68, 1922 (1946); J. W. Scheeren et al., Synthesis 1978, 283.

Octhilinone CAS Registry Number: 26530-20-1 2-正辛基-4-异噻唑啉-3-酮

CAS Name: 2-Octyl-3(2H)-isothiazolone
Additional Names: 2-octyl-4-isothiazolin-3-oneTrademarks: Kathon (Rohm Haas)
Percent Composition: C 61.93%, H 8.98%, N 6.57%, O 7.50%, S 15.03%
Literature References: Prepn: S. N. Lewis et al., FR 1555416 corresp to US 3761488 (1969, 1973 to Rohm Haas); eidem, J. Heterocycl. Chem. 8, 571 (1971).

Pirenoxine CAS Registry Number: 1043-21-6 吡诺克辛

CAS Name: 1-Hydroxy-5-oxo-5H-pyrido[3,2-a]phenoxazine-3-carboxylic acid
Additional Names: 1-hydroxy-5H-pyrido[3,2-a]phenoxazin-5-one-3-carboxylic acid; 1-hydroxy-3-carboxy-5H-pyrido[3,2-a]pheno...
Literature References: Prepn: S. Ogino, JP 59 2227, C.A. 54, 11058i (1960); S. Ishii, JP 61 1782, C.A. 55, 21494e (1961) (1959, 1961 both to Chizu Drug); of the sodium salt: S. Ishii, K. Ogata, JP 73 2672 (1973 to Senju), C.A. 80, 6959t (1974). Pharmacological studies: F. Ikemoto et al., Oyo Yakuri 8, 937 (1974), C.A. 83, 71663t (1975). Toxicological studies: eidem, ibid. 911, 923, C.A. 82, 51617g, 68262k (1975). Influence on carbohydrate metabolism in the lens: I. Korte et al., Ophthalmic Res. 7, 282 (1975). Effect on NADH, NADPH: eidem, ibid. 440. Effect on senile cataracts: T. Murata, Folia Ophthalmol. Jpn. 31, 1217 (1980). Clinical trial in treatment of cataracts: S. K. Angra et al., Indian J. Ophthalmol. 31, 5 (1983).

Dibromopropamidine CAS Registry Number: 496-00-4 双溴丙脒

CAS Name: 4,4'-[1,3-Propanediylbis(oxy)]bis(3-bromobenzenecarboximidamide)
Additional Names: 4,4'-(trimethylenedioxy)bis(3-bromobenzamidine); 2',2''-dibromo-4',4''-diamidino-1,3-diphenoxypropan...
Literature References: Prepn: S. S. Berg, G. Newbery, GB 598911 (1948 to May Baker); eidem, J. Chem. Soc. 1949, 642. Antibacterial activity: R. Wien et al., Lancet 254, 711 (1948); A. D. Russell, J. R. Furr, Int. J. Pharm. 34, 115 (1986). Mode of action: W. Woodside, Microbios 8, 23 (1973). Clinical use in Acanthamoeba keratitis: J. J. Wiens, W. B. Jackson, Can. J. Ophthalmol. 23, 107 (1988). HPLC determn in cosmetics: B. Wyhowski de Bukanski, M. O. Masse, Int. J. Cosmet. Sci. 6, 283 (1984).

Lorcainide CAS Registry Number: 59729-31-6 洛开酰胺

CAS Name: N-(4-Chlorophenyl)-N-[1-(1-methylethyl)-4-piperidinyl]benzeneacetamide
Additional Names: 4'-chloro-N-(1-isopropyl-4-piperidyl)-2-phenylacetanilide
Percent Composition: C 71.24%, H ...
Literature References: Prepn: S. Sanczuk, H. K. F. Hermans, DE 2642856 (1977 to Janssen), C.A. 87, 53094 (1977); eidem, US 4126689 (1978 to Janssen). Determn of lorcainide and its metabolites by GLC: R. Woestenborghs et al., J. Chromatogr. 164, 169 (1979). Disposition and anti-arrhythmic effects: U. Klotz et al., Int. J. Clin. Pharmacol. Biopharm. 17, 152 (1979). Pharmacokinetics and tissue distribution: U. Klotz, E. Golbs, Arzneim.-Forsch. 30, 619 (1980). Clinical study: P. Somani, S. di Giorgi, Chest 78, 658 (1980). Toxicology: G. J. Barton, R. Marsboom, "A Brief Summary of Animal Toxicology Studies on Lorcainide", in Prognosis and Pharmacotherapy of Life-Threatening Arrhythmias, Jähnchen et al., Eds. (Royal Soc. Med. London, 1981) pp 23-25. Review of pharmacology and efficacy: C. E. Eriksson, R. N. Brogden, Drugs 27, 279-300 (1984). Symposium: Am. J. Cardiol. 54, 1B-54B (1984).

Demexiptiline CAS Registry Number: 24701-51-7 酮亏替林

CAS Name: 5H-Dibenzo[a,d]cyclohepten-5-one O-[2-(methylamino)ethyl]oxime
Percent Composition: C 77.67%, H 6.52%, N 10.06%, O 5.75%
Literature References: Prepn: S. Schütz et al., DE 1247302; eidem, US 3963778 (1967, 1976 both to Bayer). Synthesis and pharmacological properties: G. Aichinger et al., Arzneim.-Forsch. 19, 838 (1969); S. Rossi et al., Farmaco Ed. Sci. 24, 685 (1969).

Haloprogin CAS Registry Number: 777-11-7 氯丙炔碘

CAS Name: 1,2,4-Trichloro-5-[(3-iodo-2-propynyl)oxy]benzene
Additional Names: 3-iodo-2-propynyl 2,4,5-trichlorophenyl ether; 2,4,5-trichlorophenyl g-iodopropargyl etherTrademarks: Halotex (BMS)...
Literature References: Prepn: S. Seki et al., Agric. Biol. Chem. 27, 150 (1963), C.A. 58, 14635g (1963); eidem, JP 64 19791; eidem, US 3322813 (1964, 1967 both to Meiji Seika). Pharmacology: S. Seki et al., Antimicrob. Agents Chemother. 1963, 569; E. F. Harrison et al., Appl. Microbiol. 19, 746 (1970).

Fursultiamine CAS Registry Number: 804-30-8 呋喃硫胺

CAS Name: N-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-N-[4-hydroxy-1-methyl-2-[[(tetrahydro-2-furanyl)methyl]dithio]-1-butenyl]formamide
Additional Names: thiamine tetrahydrofurfuryl disulfide Literature References: Prepn: S. Yurugi, T. Fushimi, US 3016380 (1962 to Takeda). Metabolism: S. Kikuchi et al., Eur. J. Pharmacol. 9, 367 (1970); C. Mitoma, Drug Metab. Dispos. 1, 698 (1973). Series of papers on function of tetrahydrofurfuryl mercaptan moiety: J. Biochem. 74, 717 (1973). Crystal structure: W. Shin, Y. C. Kim, Bull. Korean Chem. Soc. 7, 331 (1986).

Prifinium Bromide CAS Registry Number: 4630-95-9 吡芬溴铵

CAS Name: 3-(Diphenylmethylene)-1,1-diethyl-2-methylpyrrolidinium bromide
Additional Names: 3-(diphenylmethylene)-1-ethyl-2-methylpyrrolidine ethyl bromide; pyrodifenium bromide
Trademarks: ...
Literature References: Prepn: Sadao Oki, JP 65 22462 (1965), C.A. 64, 3489a (1966); of the free base: idem, JP 65 17015 (1965), C.A. 63, 18034b (1965). Ganglion blocking agent. Metabolism: Nakai et al., Arzneim.-Forsch. 20, 1112 (1970). Toxicity studies: Kumada et al., ibid. 22, 706 (1972).