其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Biphenamine CAS Registry Number: 3572-52-9 2-二乙基氨基--苯基水杨酸乙酯

Additional Names: b-Diethylaminoethyl 2-hydroxy-3-phenylbenzoate; 2-diethylaminoethyl 3-phenylsalicylate; 2-diethylaminoethyl 2-hydroxy-3-biphenylcarboxylate; 3-phenylsalicylic acid 2-diethylamino...
Literature References: Prepn: Sahyun, US 2594350 (1952).

HMPA CAS Registry Number: 680-31-9 六甲磷酰三胺(HMPA)

CAS Name: Hexamethylphosphoric triamide
Additional Names: hexamethylphosphoramide; hexametapol; hempa; HMPTPercent Composition: C 40.21%, H 10.12%, N 23.45%, O 8.93%, P 17.28%
Literature References: Prepn: Saul, Godfrey, US 2752392 (1956 to Monsanto); Godfrey, US 2852550 (1958 to Monsanto); Miller, Lomonte, US 3084190 (1963 to Dow); Vetter, Noeth, Ber. 96, 1308 (1963). Solvation effects: J. E. Dubois, A. Bienvenue, Tetrahedron Lett. 1966, 1809. Toxicity studies: T. B. Gaines, Toxicol. Appl. Pharmacol. 14, 515 (1969). Carcinogenicity studies: J. A. Zapp, Science 190, 422 (1975); IARC Monographs 15, 211 (1977). Review: H. Normant, Angew. Chem. Int. Ed. 6, 1047 (1967).

Eprozinol CAS Registry Number: 32665-36-4 依普罗醇

CAS Name: 4-(2-Methoxy-2-phenylethyl)-a-phenyl-1-piperazinepropanol
Additional Names: 1-(2-methoxy-2-phenylethyl)-4-(3-hydroxy-3-phenylpropyl)piperazine
Percent Composition: C 74.54%, H 8.53...
Literature References: Prepn: Saunders, GB 1188505 (1970); to R. Y. Mauvernay, N. Busch, US 3705244 (1972). Pharmacology: Duchene-Marullaz et al., Therapie 26, 155 (1971). Clinical studies: Sors, Dutarte, ibid. 163.

Methyl 4-Pyridyl Ketone Thiosemicarbazone CAS Registry Number: 3115-21-7 (1-吡啶-4-基乙亚基氨基)硫脲

CAS Name: 2-[1-(4-Pyridinyl)ethylidene]hydrazinecarbothioamide
Percent Composition: C 49.46%, H 5.19%, N 28.84%, S 16.51%
Literature References: Prepn: Schäfer et al., US 2744905 (1956 to Schenley).

Methiotriazamine CAS Registry Number: 6043-86-3 甲硫三嗪胺盐酸盐

CAS Name: 1,6-Dihydro-6,6-dimethyl-1-[4-(methylthio)phenyl]-1,3,5-triazine-2,4-diamine
Additional Names: 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-[p-(methylthio)phenyl]-s-triazine; 4,6-diamino-1-...
Literature References: Prepn: Schalit, Cutler, J. Org. Chem. 24, 573 (1959).

Tromantadine CAS Registry Number: 53783-83-8 曲金刚胺

CAS Name: 2-[2-(Dimethylamino)ethoxy]-N-tricyclo[3.3.1.13,7]dec-1-ylacetamide
Additional Names: N-1-adamantyl-N-[2-(dimethylamino)ethoxy]acetamide; 1-(dimethylaminoethoxyacetamido)adamantane Literature References: Prepn: Scherm, Peteri, DE 1941218 (1971 to Merz), C.A. 74, 99516k (1971); May, Peteri, Arzneim.-Forsch. 23, 718 (1973). Chemistry and toxicology: Peteri, Sterner, ibid. 577.

Cloflucarban CAS Registry Number: 369-77-7 N-(4-氯苯基)-N'-[4-氯-3-(三氟甲基)苯基]脲

CAS Name: N-(4-Chlorophenyl)-N'-[4-chloro-3-(trifluoromethyl)phenyl]urea
Additional Names: 4,4'-dichloro-3-(trifluoromethyl)carbanilide
Trademarks: Irgasan CF3
Percent Composition: C 48.1...
Literature References: Prepn: Schetty et al., US 2745874 (1956 to Geigy); Sydor, BE 617117 (1962 to Am. Cyanamid), compd included but not specifically described in abstract, C.A. 59, 1542a (1963).

Pyrrocaine CAS Registry Number: 2210-77-7 吡咯卡因

CAS Name: N-(2,6-Dimethylphenyl)-1-pyrrolidineacetamide
Additional Names: 1-pyrrolidineaceto-2',6'-xylidide; 2-(1-pyrrolidinyl)-2',6'-acetoxylidide; 1-pyrrolidinoaceto-2,6-dimethylanilideTradem...
Literature References: Prepn: Schlesinger, Gordon, US 2813861 (1957 to Endo); Löfgren et al., Acta Chem. Scand. 11, 1724 (1957).

Distigmine Bromide CAS Registry Number: 15876-67-2 溴地斯的明

CAS Name: 3,3'-[1,6-Hexanediylbis[(methylimino)carbonyl]oxy]bis[1-methylpyridinium]dibromide
Additional Names: 3-hydroxy-1-methylpyridinium bromide hexamethylenebis[methylcarbamate]; hexamethyl...
Literature References: Prepn: Schmid, US 2789981 (1957 to Oesterr. Stickstoffwerke). Pharmacology: Hertting et al., Arzneim.-Forsch. 18, 479 (1968); Hohenegger, Lindner, Wien. Klin. Wochenschr. 81, 823 (1969). Stability studies: Suzuki, Tanimura, Yakugaku Zasshi 90, 762 (1970).

Demecarium Bromide CAS Registry Number: 56-94-0 地美溴铵

CAS Name: 3,3'-[1,10-Decanediylbis[(methylimino)carbonyloxy]]bis[N,N,N-trimethylbenzenaminium]dibromide
Additional Names: (m-hydroxyphenyl)trimethylammonium bromide, decamethylenebis(methylcarb...
Literature References: Prepn: Schmid, US 2789981 (1957 to Oesterreichische Stickstoffwerke).