其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

g -Carboline CAS Registry Number: 244-69-9 5H-吡啶并[4,3-b]吲哚

CAS Name: 5H-Pyrido[4,3-b]indole
Additional Names: 2H-pyrid[4,3-b]indole; 5-carboline
Percent Composition: C 78.55%, H 4.79%, N 16.66%
Literature References: Prepn: Robinson, Thornley, J. Chem. Soc. 125, 2169 (1924). Prepn of derivs: Hörlein, Ber. 87, 463 (1954); C. Ducrocq et al., J. Heterocycl. Chem. 12, 963 (1975). NMR studies: F. Balkau, M. L. Heffernan, Aust. J. Chem. 26, 1501, 1523 (1973).

Betasine CAS Registry Number: 3734-24-5 3-氨基-3-(3,5-二碘-4-羟基苯基)丙酸

CAS Name: b-Amino-4-hydroxy-3,5-diiodobenzenepropanoic acid
Additional Names: b-amino-4-hydroxy-3,5-diiodohydrocinnamic acid; b-(4-hydroxy-3,5-diiodophenyl)-b-alanine; b-(4-hydroxy-3,5-diiodoph...
Literature References: Prepn: Rodionov et al., Zh. Obshch. Khim. 27, 2234 (1957); Suvorov et al., SU 104779 (1957), C.A. 51, 8794b (1957).

Amprolium CAS Registry Number: 121-25-5 安普罗铵

CAS Name: 1-[(4-Amino-2-propyl-5-pyrimidinyl)methyl]-2-methylpyridinium chloride
Additional Names: 1-[(4-amino-2-propyl-5-pyrimidinyl)methyl]-2-picolinium chloride
Trademarks: Corid (Merck ...
Literature References: Prepn: Rogers et al., J. Am. Chem. Soc. 82, 2974 (1960); Rogers, Sarett, US 3020277 (1962 to Merck Co.), see also US 3020200. Formulations as poultry feed: Rogers, Sarett, US 3065132 (1962 to Merck Co.).

Cyclopentamine CAS Registry Number: 102-45-4 1-环戊基-N-甲基丙-2-胺

CAS Name: N,a-Dimethylcyclopentaneethanamine
Additional Names: N,a-dimethylcyclopentaneethylamine; 1-cyclopentyl-2-methylaminopropane; b-(methylamino)propylcyclopentane; cyclopentadrine
Trad...
Literature References: Prepn: Rohrmann, US 2520015 (1950 to Lilly).

Protheobromine CAS Registry Number: 50-39-5 氟氯西林

CAS Name: 3,7-Dihydro-1-(2-hydroxypropyl)-3,7-dimethyl-1H-purine-2,6-dione
Additional Names: 1-(2-hydroxypropyl)theobromine
Trademarks: Tebe (Simes); Bonicor (Farmetrusca)
Percent Composi...
Literature References: Prepn: Rojahn, Fegler, Arch. Pharm. 268, 570 (1930); GB 816299 (1959 to Chemiewerk Homburg), cf. DE 1067025. Improved procedure: Carstens, Donat, DD 26757 (1964). Pharmacology: Giertz et al., Arzneim.-Forsch. 6, 457 (1956). Toxicity study: R. Taugner et al., Arzneim.-Forsch. 6, 601 (1956).

Benzyl Sulfide CAS Registry Number: 538-74-9 二苄基硫醚

CAS Name: 1,1'-[Thiobis(methylene)]bisbenzene
Additional Names: dibenzylsulfide
Percent Composition: C 78.45%, H 6.58%, S 14.96%
Literature References: Prepn: Runge et al., J. Prakt. Chem. 11, 284 (1960). Manuf from benzyl chloride and Na2S: Stucker, Brennan, US 2755305 (1956 to Pure Oil Co.).

Buclosamide CAS Registry Number: 575-74-6 丁氯柳胺

CAS Name: N-Butyl-4-chloro-2-hydroxybenzamide
Additional Names: N-butyl-4-chlorosalicylamide; 4-chloro-2-hydroxybenzoic acid n-butylamide
Percent Composition: C 58.03%, H 6.20%, Cl 15.57%, N...
Literature References: Prepn: Ruschig et al., US 2923737 (1960 to Hoechst).

Tyropanoate Sodium CAS Registry Number: 7246-21-1 酪泮酸钠

CAS Name: a-Ethyl-2,4,6-triiodo-3-[(1-oxobutyl)amino]benzenepropanoic acid monosodium salt
Additional Names: 3-butyramido-a-ethyl-2,4,6-triiodohydrocinnamic acid sodium salt; a-ethyl-b-(2,4,6-t...
Literature References: Prepn: S. Archer, J. O. Hoppe, US 2895988 (1959 to Sterling Drug); and pharmacology: J. O. Hoppe et al., J. Med. Chem. 13, 997 (1970). Clinical trials: S. Y. Han, D. M. Witten, Radiology 112, 529 (1974); R. F. Thoeni, A. A. Moss, ibid. 144, 271 (1982).

Aldioxa CAS Registry Number: 5579-81-7 尿囊素铝

CAS Name: [(2,5-Dioxo-4-imidazolidinyl)ureato]dihydroxyaluminum
Additional Names: (allantoinato)dihydroxyaluminum; dihydroxy[(4,5-dihydro-2-hydroxy-5-oxo-1H-imidazol-4-yl)ureato]aluminum; alumi...
Literature References: Prepn: S. B. Mecca, US 2761867 (1956 to Schuylkill Chem.). Pharmacology: R. Cahen, J. F. Clement, Ann. Pharm. Fr. 20, 693 (1962); R Cahen, A. Pessonnier, ibid. 704. Toxicology: R. Cahen, A. Pessonnier, ibid. 623. Metabolism studies: K. Fukawa et al., Oyo Yakuri 11, 421 (1976), C.A. 88, 130701g (1978). HPLC determn in plasma: K. Hirota et al., J. Chromatogr. 277, 165 (1983). Clinical studies of combination therapy for peptic ulcer: M. Sakai et al., Jpn. Arch. Intern. Med. 31, 275 (1984); idem et al., ibid. 33, 61 (1986); idem et al., ibid. 36, 357 (1989). Review of cosmetic use and safety assessment: S. N. J. Pang, J. Am. Coll. Toxicol. 12, 237-242 (1993).

Nitralin CAS Registry Number: 4726-14-1 甲磺乐灵

CAS Name: 4-(Methylsulfonyl)-2,6-dinitro-N,N-dipropylbenzenamine
Additional Names: 4-(methylsulfonyl)-2,6-dinitro-N,N-dipropylanilineTrademarks: Planavin (Shell)
Percent Composition: C 45.21...
Literature References: Prepn: S. B. Soloway, K. D. Swahlen, US 3227734 and US 3321292 (1966, 1967 both to Shell). Persistence in the soil: J. H. Miller et al., Weed Sci. 23, 211 (1975). Determn by GC in biological fluids: T. Kumazawa et al., J. Anal. Toxicol. 19, 95 (1995); by LC in soil: N. Ruiz de Erenchun et al., J. Chromatogr. A 763, 227 (1997).