其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Oxypendyl CAS Registry Number: 5585-93-3 奥昔喷地

CAS Name: 4-[3-(10H-Pyrido[3,2-b][1,4]benzothiazin-10-yl)propyl]-1-piperazineethanol
Additional Names: 10-[3-[4-(2-hydroxyethyl)-1-piperazinyl]propyl]-10H-pyrido[3,2-b][1,4]benzothiazine; 10-[3...
Literature References: Prepn: Schuler, Klebe, Ann. 653, 172 (1962).

Dichlorphenamide CAS Registry Number: 120-97-8 双氯非那胺

CAS Name: 4,5-Dichloro-1,3-benzenedisulfonamide
Additional Names: 1,3-disulfamyl-4,5-dichlorobenzene; 4,5-dichloro-1,3-disulfamoylbenzene
Trademarks: Antidrasi; Daranide (Merck Co.); Oratro...
Literature References: Prepn: Schultz, US 2835702 (1958 to Merck Co.).

Amphenidone CAS Registry Number: 134-37-2 安非尼酮

CAS Name: 1-(3-Aminophenyl)-2(1H)-pyridinone
Additional Names: 1-(m-aminophenyl)-2(1H)-pyridone
Percent Composition: C 70.95%, H 5.41%, N 15.04%, O 8.59%
Literature References: Prepn: Scudi et al., US 2947754 (1960 to Wallace Tiernan). Toxicity data: Plekss et al., Fed. Proc. 19, 390 (1960).

Oxethazaine CAS Registry Number: 126-27-2 奥昔卡因

CAS Name: 2,2'-[(2-Hydroxyethyl)imino]bis[N-(1,1-dimethyl-2-phenylethyl)-N-methylacetamide]
Additional Names: N,N-bis[N-methyl-N-phenyl-tert-butylacetamido]-b-hydroxyethylamine; oxetacaine; oxe...
Literature References: Prepn: Seifter et al., US 2780646 (1957 to Am. Home Prods.); Salomon, IL 10062 (1957), C.A. 52, 15569 (1958). Pharmacology: Axerio Agnessetti, An. R. Acad. Farm. 35, 183 (1969), C.A. 71, 122082q (1969). Toxicity studies: J. M. Glassman et al., Toxicol. Appl. Pharmacol. 5, 184 (1963). Clinical trial of combination with antacid in ulcer pain: F. T. M. Cordeiro et al., Curr. Ther. Res. 19, 230 (1976); A. Zanni et al., Curr. Med. Res. Opin. 10, 128 (1986). Evaluation as dental anesthetic: P. A. Brennan, J. D. Langdon, Br. J. Oral Maxillofac. Surg. 28, 26 (1990).

Dimethylglyoxime CAS Registry Number: 95-45-4 丁二酮肟

CAS Name: 2,3-Butanedionedioxime
Additional Names: diacetyldioxime; Chugaev's reagent
Percent Composition: C 41.37%, H 6.94%, N 24.12%, O 27.56%
Literature References: Prepn: Semon, Damerell, Org. Synth. coll. vol. II, 204 (1943). Manuf: Kamlet, US 2732404 (1956 to National Distillers Product Corp.). Crystal structure: Anal. Chem. 21, 1428 (1949); Merritt, Lanterman, Acta Crystallogr. 5, 811 (1952).

Bucolome CAS Registry Number: 841-73-6 丁基环已基巴比妥

CAS Name: 5-Butyl-1-cyclohexyl-2,4,6(1H,3H,5H)pyrimidinetrione
Additional Names: 5-butyl-1-cyclohexylbarbituric acid; 5-n-butyl-1-cyclohexyl-2,4,6-trioxoperhydropyrimidine; BCP
Trademarks: P...
Literature References: Prepn: Senda et al., US 3243344 and US 3274195 (both 1966 to Takeda). Metabolic studies in man: Yashiki et al., Chem. Pharm. Bull. 19, 468, 869 (1971).

Hexetidine CAS Registry Number: 141-94-6 海克替啶,立体异构体混合物

CAS Name: 1,3-Bis(2-ethylhexyl)hexahydro-5-methyl-5-pyrimidinamine
Additional Names: 5-amino-1,3-bis(2-ethylhexyl)hexahydro-5-methylpyrimidine; 1,3-bis(b-ethylhexyl)-5-methyl-5-aminohexahydropy...
Literature References: Prepn: Senkus, J. Am. Chem. Soc. 68, 1611 (1946); US 2415047; Bell, Necker, US 3054797 (1947, 1962 both to Comm. Solvents Corp.). Comprehensive description: G. Satzinger et al., Anal. Profiles Drug Subs. 7, 277-295 (1978).

Phenformin CAS Registry Number: 114-86-3 N-苯乙基双胍

CAS Name: N-(2-Phenylethyl)imidodicarbonimidic diamide
Additional Names: 1-phenethylbiguanide; phenethyldiguanide; N'-b-phenethylformamidinyliminourea; fenformin; fenormin; b-PEBG; PEDG
Perc...
Literature References: Prepn: Shapiro et al., J. Am. Chem. Soc. 81, 2220 (1959); Shapiro, Freedman, US 2961377; US 3057780 (1960, 1962 both to U.S.V.). Metabolism: R. Beckmann, Diabetologia 3, 368 (1967). Association with lactic acidosis in diabetic patients: R. I. Misbin, Ann. Intern. Med. 87, 591 (1977). Toxicity study: G. Proske et al., Arzneim.-Forsch. 12, 314 (1962). Comprehensive description: J. E. Moody, Anal. Profiles Drug Subs. 4, 319-332 (1975). Review of phenformin-induced lactic acidosis: M. E. McGuinness, R. L. Talbert, Ann. Pharmacother. 27, 1183-1187 (1993).

p-Lactophenetide CAS Registry Number: 539-08-2 N-乳酰对苯乙定

CAS Name: N-(4-Ethoxyphenyl)-2-hydroxypropanamide
Additional Names: p-lactophenetidide; lactyl-p-phenetidin-N-(p-ethoxyphenyl)lactamide
Trademarks: Fenolactine; Lactophenin; Phenolactine
...
Literature References: Prepn: Shapiro et al., J. Am. Chem. Soc. 81, 6322 (1959).

Ambuphylline CAS Registry Number: 5634-34-4 安布茶碱

CAS Name: 3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione compd with 2-amino-2-methyl-1-propanol (1:1)
Additional Names: theophylline aminoisobutanol; theophylline compd with 2-amino-2-methyl-1-pr...
Literature References: Prepn: Shelton, US 2404319 (1946 to Wm. S. Merrell). Toxicity studies: Thompson, Warren, J. Clin. Med. 31, 1337 (1946).